DMSO-Promoted Difluoroalkylation of Organophosphonium Salts with Difluoroenol Silyl Ethers.
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DOI: 10.1021/acs.orglett.2c02088
Abstract: An efficient method for the synthesis of β,β-di(hetero)aryl-α,α-difluorinated ketones using readily available organophosphonium salts and difluoroenol silyl ethers has been developed. This mild reaction features a good functional group tolerance, a scaled-up synthesis, and synthetic… read more here.
Keywords: salts difluoroenol; difluoroenol silyl; silyl ethers; organophosphonium salts ... See more keywords