The NAD+ Salvage Pathway Supports PHGDH-Driven Serine Biosynthesis.
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DOI: 10.1016/j.celrep.2018.07.086
Abstract: NAD+ is a key metabolic redox cofactor that is regenerated from nicotinamide through the NAD+ salvage pathway. Here, we find that inhibiting the NAD+ salvage pathway depletes serine biosynthesis from glucose by impeding the NAD+-dependent protein,… read more here.
Keywords: serine biosynthesis; salvage pathway; nad salvage; salvage ... See more keywords
TLR8 is activated by 5'-methylthioinosine, a Plasmodium falciparum-derived intermediate of the purine salvage pathway.
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DOI: 10.1016/j.celrep.2022.110691
Abstract: The innate immune recognition of the malaria-causing pathogen Plasmodium falciparum (P. falciparum) is not fully explored. Here, we identify the nucleoside 5'-methylthioinosine (MTI), a Plasmodium-specific intermediate of the purine salvage pathway, as a pathogen-derived Toll-like receptor… read more here.
Keywords: plasmodium; intermediate purine; purine salvage; salvage pathway ... See more keywords
Participation of the adenosine salvage pathway and cyclic AMP modulation in oocyte energy metabolism
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DOI: 10.1038/s41598-019-54693-y
Abstract: A follicular spike in cyclic AMP (cAMP) and its subsequent degradation to AMP promotes oocyte maturation and ovulation. In vitro matured (IVM) oocytes do not receive the cAMP increase that occurs in vivo, and artificial… read more here.
Keywords: atp; camp; amp; salvage pathway ... See more keywords
Revisiting the methionine salvage pathway and its paralogues
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DOI: 10.1111/1751-7915.13324
Abstract: Methionine is essential for life. Its chemistry makes it fragile in the presence of oxygen. Aerobic living organisms have selected a salvage pathway (the MSP) that uses dioxygen to regenerate methionine, associated to a ratchet‐like… read more here.
Keywords: salvage pathway; methionine salvage; salvage; pathway paralogues ... See more keywords
The fucose salvage pathway inhibits invadopodia formation and extracellular matrix degradation in melanoma cells
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DOI: 10.1371/journal.pone.0199128
Abstract: The fucose salvage pathway is a two-step process in which mammalian cells transform L-fucose into GDP-L-fucose, a universal fucose donor used by fucosyltransferases to modify glycans. Emerging evidence indicates the fucose salvage pathway and the… read more here.
Keywords: melanoma; salvage pathway; fucose salvage; formation ... See more keywords
Inhibition of the NAD salvage pathway in schistosomes impairs metabolism, reproduction, and parasite survival
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DOI: 10.1371/journal.ppat.1008539
Abstract: NAD, a key co-enzyme required for cell metabolism, is synthesized via two pathways in most organisms. Since schistosomes apparently lack enzymes required for de novo NAD biosynthesis, we evaluated whether these parasites, which infect >200… read more here.
Keywords: metabolism; salvage pathway; pathway schistosomes; inhibition nad ... See more keywords
Hypoxanthine Reduces Radiation Damage in Vascular Endothelial Cells and Mouse Skin by Enhancing ATP Production via the Salvage Pathway
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DOI: 10.1667/rade-21-00223.1
Abstract: An effective method that can protect radiation-damaged tissues from apoptosis and promote tissue repair has not been reported to date. Hypoxanthine (Hx) is an intermediate metabolite in the purine degradation system that serves as a… read more here.
Keywords: damage; via salvage; endothelial cells; radiation ... See more keywords