Protective effects of salvianolic acid A on clozapine‐induced cardiotoxicity in zebrafish
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4368
Abstract: The clinical use of clozapine (CLZ), an atypical antipsychotic drug, was affected by side effects, such as cardiotoxicity. We selected normally developing zebrafish embryos to explore the antagonism of salvianolic acid A (SAA) against clozapine‐induced… read more here.
Keywords: induced cardiotoxicity; cardiotoxicity; salvianolic acid; clozapine induced ... See more keywords
Salvianolic acid inhibits the effects of high glucose on vascular endothelial dysfunction by modulating the Sirt1‐eNOS pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22245
Abstract: Salvianolic acid (SA) is known for improving blood circulation, scavenging hydroxyl radicals, and preventing platelet aggregation. The research explored whether SA can protect against cardiovascular disease induced by high glucose conditions. Our results indicate that… read more here.
Keywords: sirt1 enos; modulating sirt1; enos pathway; salvianolic acid ... See more keywords
Salvianolic acid B blocks hepatic stellate cell activation via FGF19/FGFR4 signaling.
Sign Up to like & getrecommendations! Published in 2020 at "Annals of hepatology"
DOI: 10.1016/j.aohep.2020.07.013
Abstract: INTRODUCTION AND OBJECTIVES The activation of hepatic stellate cells (HSCs) is the main cause of liver fibrosis. The beneficial effects of fibroblast growth factor (FGF) 19 on liver fibrosis were recently reported. The S. miltiorrhiza… read more here.
Keywords: fgf19 fgfr4; salvianolic acid; fgfr4 signaling; activation ... See more keywords
Salvianolic acid B attenuates oxidative stress-induced injuries in enterocytes by activating Akt/GSK3β signaling and preserving mitochondrial function.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174408
Abstract: The cellular and tissue damage induced by oxidative stress (OS) contribute to a variety of human diseases, which include gastrointestinal diseases. Salvianolic acid B (Sal B), which is a natural polyphenolic acid in Salvia miltiorrhiza,… read more here.
Keywords: gsk3 signaling; oxidative stress; salvianolic acid; stress induced ... See more keywords
Salvianolic acid A inhibits the growth of diffuse large B-cell lymphoma through MAPK pathways.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental hematology"
DOI: 10.1016/j.exphem.2020.11.007
Abstract: Treatment options are limited in patients with diffuse large B-cell lymphoma (DLBCL). Salvianolic acid A (SAA) is a water-soluble phenolic acid extracted from Salvia miltiorrhiza (Danshen) with anti-tumor properties. The anti-leukemic activity of SAA that… read more here.
Keywords: saa; salvianolic acid; large cell; diffuse large ... See more keywords
SmbHLH53 Is Relevant to Jasmonate Signaling and Plays Dual Roles in Regulating the Genes for Enzymes in the Pathway for Salvianolic Acid B Biosynthesis in Salvia miltiorrhiza.
Sign Up to like & getrecommendations! Published in 2020 at "Gene"
DOI: 10.1016/j.gene.2020.144920
Abstract: Basic helix-loop-helix (bHLH) transcription factors play essential roles in myriad regulatory processes, including secondary metabolism. In this study with Salvia miltiorrhiza, we isolated and characterized SmbHLH53, which encodes a bHLH family member. Expression of this… read more here.
Keywords: genes enzymes; salvianolic acid; enzymes pathway; salvia miltiorrhiza ... See more keywords
Salvianolic acid B and ferulic acid synergistically promote angiogenesis in HUVECs and zebrafish via regulating VEGF signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.114667
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Induced vascular growth in the myocardium has been widely acknowledged as a promising intervention strategy for patients with ischemic coronary artery disease. Yet despite long-term efforts on gene, protein or cell-based pro-angiogenic therapies,… read more here.
Keywords: medicine; pro angiogenic; angiogenesis; salvianolic acid ... See more keywords
Simultaneous determination and pharmacokinetic study of four phenolic acids in rat plasma using UFLC–MS/MS after intravenous administration of salvianolic acid for injection
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2016.10.017
Abstract: HIGHLIGHTSDevelopment of a sensitive and selective ultra‐fast liquid chromatography‐tandem mass spectrometry (UFLC–MS/MS) method.Application of UFLC–MS/MS for the determination of RA, sal D, LA and sal B in SAFI in rat plasma.The first pharmacokinetic study of… read more here.
Keywords: rat plasma; salvianolic acid; acid injection; acid ... See more keywords
De novo Biosynthesis of Salvianolic Acid B in Saccharomyces cerevisiae Engineered with the Rosmarinic Acid Biosynthetic Pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c06329
Abstract: Salvianolic acid B (SAB), also named lithospermic acid B, belongs to a class of water-soluble phenolic acids, originating from plants such as Salvia miltiorrhiza. SAB exhibits a variety of biological activities and has been clinically… read more here.
Keywords: sab; novo biosynthesis; biosynthetic pathway; salvianolic acid ... See more keywords
Mechanism-based pharmacokinetic–pharmacodynamic modeling of salvianolic acid A effects on plasma xanthine oxidase activity and uric acid levels in acute myocardial infarction rats
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DOI: 10.1080/00498254.2016.1180440
Abstract: Abstract 1. Salvianolic acid A (SalA) was found to attenuate plasma uric acid (UA) concentration and xanthine oxidase (XO) activity in acute myocardial infraction (AMI) rats, which was characterized with developed mechanism-based pharmacokinetic–pharmacodynamic (PK-PD) model. 2. AMI… read more here.
Keywords: uric acid; sala; plasma; salvianolic acid ... See more keywords
Evaluation of the anti-inflammatory and antioxidant pharmcodynamic compoents of naoxintong capsules as a basis of broad spectrum effects
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2020.1870506
Abstract: Abstract Context Naoxintong capsule (NXT) is one of the most prevalent Traditional Chinese Medicine formulations in the treatment of coronary heart disease (CHD), yet the action of pharmacodynamic components remains unclear. Objective To determine the… read more here.
Keywords: anti inflammatory; evaluation anti; basis; salvianolic acid ... See more keywords