Enhancement of safety and immunogenicity of the Chinese Hu191 measles virus vaccine by alteration of the S-adenosylmethionine (SAM) binding site in the large polymerase protein
Sign Up to like & getrecommendations! Published in 2018 at "Virology"
DOI: 10.1016/j.virol.2018.02.022
Abstract: Abstract The live-attenuated measles virus (MV) vaccine based on the Hu191 strain has played a significant role in controlling measles in China. However, it has considerable adverse effects that may cause public health burden. We… read more here.
Keywords: virus vaccine; binding site; hu191; sam binding ... See more keywords
Zn2+-Induced Conformational Change Affects the SAM Binding in a Mycobacterial SAM-Dependent Methyltransferase
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DOI: 10.1021/acsomega.2c04555
Abstract: Zinc is a cofactor for enzymes involved in DNA replication, peptidoglycan hydrolysis, and pH maintenance, in addition to the transfer of the methyl group to thiols. Here, we discovered a new role of Zn2+ as… read more here.
Keywords: sam; zn2 induced; binding mycobacterial; sam binding ... See more keywords
Insertions and deletions mediated functional divergence of Rossmann fold enzymes
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DOI: 10.1101/2022.05.16.491946
Abstract: Nucleobase-containing coenzymes are considered the relics of an early RNA-based world that preceded the emergence of protein domains. Despite the importance of coenzyme-protein synergisms, their emergence and evolution remain poorly understood. An excellent target to… read more here.
Keywords: rossmann; insertions deletions; coenzyme; sam binding ... See more keywords