Decoding the Identification Mechanism of an SAM-III Riboswitch on Ligands through Multiple Independent Gaussian-Accelerated Molecular Dynamics Simulations
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c00961
Abstract: S-Adenosyl-l-methionine (SAM)-responsive riboswitches play a central role in the regulation of bacterial gene expression at the level of transcription attenuation or translation inhibition. In this study, multiple independent Gaussian-accelerated molecular dynamics simulations were performed to… read more here.
Keywords: independent gaussian; sam; multiple independent; identification ... See more keywords
SAM-VI RNAs selectively bind S-adenosylmethionine and exhibit similarities to SAM-III riboswitches
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DOI: 10.1080/15476286.2017.1399232
Abstract: ABSTRACT Five distinct riboswitch classes that regulate gene expression in response to the cofactor S-adenosylmethionine (SAM) or its metabolic breakdown product S-adenosylhomocysteine (SAH) have been reported previously. Collectively, these SAM- or SAH-sensing RNAs constitute the… read more here.
Keywords: sam iii; bind adenosylmethionine; sam rnas; selectively bind ... See more keywords