Characterization of a Radical SAM Oxygenase for the Ether Crosslinking in Darobactin Biosynthesis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c05565
Abstract: Darobactin A is a ribosomally synthesized, post-translationally modified peptide (RiPP) with potent and broad-spectrum anti-Gram-negative antibiotic activity. The structure of darobactin A is characterized by an ether and C-C crosslinking. However, the specific mechanism of… read more here.
Keywords: radical sam; sam; sam oxygenase; ether crosslinking ... See more keywords