Sam68 Promotes Invasion, Migration, and Proliferation of Fibroblast-like Synoviocytes by Enhancing the NF-κB/P65 Pathway in Rheumatoid Arthritis
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation"
DOI: 10.1007/s10753-018-0809-4
Abstract: Src-associated substrate during mitosis of 68 KDa (Sam68), also known as KH domain containing, RNA binding, signal transduction associated 1 (KHDRBS1), is the prototypic member of the signal transduction activator of RNA (STAR) family of RNA-binding… read more here.
Keywords: fibroblast like; like synoviocytes; proliferation; migration ... See more keywords
Effective targeting of breast cancer stem cells by combined inhibition of Sam68 and Rad51
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DOI: 10.1038/s41388-022-02239-4
Abstract: Breast cancer (BC) is the second cause of cancer-related deceases in the worldwide female population. Despite the successful treatment advances, 25% of BC develops resistance to current therapeutic regimens, thereby remaining a major hurdle for… read more here.
Keywords: sam68; rad51; breast cancer; inhibition ... See more keywords
Functional Interaction Between the Oncogenic Kinase NEK2 and Sam68 Promotes a Splicing Program Involved in Migration and Invasion in Triple-Negative Breast Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.880654
Abstract: Triple-negative breast cancer (TNBC) represents the most aggressive breast cancer subtype. Poor prognosis in TNBC is partly due to lack of efficacious targeted therapy and high propensity to metastasize. Dysregulation of alternative splicing has recently… read more here.
Keywords: sam68; breast cancer; migration; tnbc ... See more keywords
DNA Damage Regulates the Functions of the RNA Binding Protein Sam68 through ATM-Dependent Phosphorylation
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DOI: 10.3390/cancers14163847
Abstract: Simple Summary Alterations of the complex network of interactions between the DNA damage response pathway and RNA metabolism have been described in several tumors, and increasing efforts are devoted to the elucidation of the molecular… read more here.
Keywords: rna binding; dna damage; sam68; phosphorylation ... See more keywords
Leptin, Adiponectin, and Sam68 in Bone Metastasis from Breast Cancer
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DOI: 10.3390/ijms21031051
Abstract: The most serious aspect of neoplastic disease is the spread of cancer cells to secondary sites. Skeletal metastases can escape detection long after treatment of the primary tumour and follow-up. Bone tissue is a breeding… read more here.
Keywords: breast cancer; bone; cancer; sam68 ... See more keywords