New Phenotypes Associated With Pathogenic RNASEH2B and SAMHD1 Variants
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Developmental Neuroscience"
DOI: 10.1002/jdn.70019
Abstract: Pathogenic variants in nine genes (AGS1‐9) were mainly reported in patients with Aicardi–Goutières syndrome (AGS), which is a genetic disorder of the innate immune response associated with improper induction of Type I interferon (IFN). These… read more here.
Keywords: pathogenic rnaseh2b; samhd1; phenotypes associated; new phenotypes ... See more keywords
Roles of SAMHD1 in antiviral defense, autoimmunity and cancer
Sign Up to like & getrecommendations! Published in 2017 at "Reviews in Medical Virology"
DOI: 10.1002/rmv.1931
Abstract: The enzyme, sterile α motif and histidine‐aspartic acid domain–containing protein 1 (SAMHD1) diminishes infection of human immunodeficiency virus type 1 (HIV‐1) by hydrolyzing intracellular deoxynucleotide triphosphates (dNTPs) in myeloid cells and resting CD4+ T cells.… read more here.
Keywords: samhd1 antiviral; hiv; antiviral defense; samhd1 ... See more keywords
Intertwined: SAMHD1 cellular functions, restriction, and viral evasion strategies
Sign Up to like & getrecommendations! Published in 2019 at "Medical Microbiology and Immunology"
DOI: 10.1007/s00430-019-00593-x
Abstract: SAMHD1 was initially described for its ability to efficiently restrict HIV-1 replication in myeloid cells and resting CD4+ T cells. However, a growing body of evidence suggests that SAMHD1-mediated restriction is by far not limited… read more here.
Keywords: samhd1 cellular; intertwined samhd1; cellular functions; samhd1 ... See more keywords
SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.08.008
Abstract: DNA double-strand break (DSB) repair by homologous recombination (HR) is initiated by CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP triphosphohydrolase, which restricts HIV-1 infection, and mutations are associated with Aicardi-Goutières… read more here.
Keywords: end resection; dna end; repair; samhd1 ... See more keywords
SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2017 at "Nature Medicine"
DOI: 10.1038/nm.4255
Abstract: The nucleoside analog cytarabine (Ara-C) is an essential component of primary and salvage chemotherapy regimens for acute myeloid leukemia (AML). After cellular uptake, Ara-C is converted into its therapeutically active triphosphate metabolite, Ara-CTP, which exerts… read more here.
Keywords: samhd1; response; myeloid leukemia; ara ... See more keywords
The SAM domain of mouse SAMHD1 is critical for its activation and regulation
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-02783-8
Abstract: Human SAMHD1 (hSAMHD1) is a retroviral restriction factor that blocks HIV-1 infection by depleting the cellular nucleotides required for viral reverse transcription. SAMHD1 is allosterically activated by nucleotides that induce assembly of the active tetramer.… read more here.
Keywords: mouse samhd1; sam domain; samhd1; domain ... See more keywords
PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation
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DOI: 10.1038/s41467-019-09867-7
Abstract: Lentiviruses have evolved to acquire an auxiliary protein Vpx to counteract the intrinsic host restriction factor SAMHD1. Although Vpx is phosphorylated, it remains unclear whether such phosphorylation indeed regulates its activity toward SAMHD1. Here we… read more here.
Keywords: restriction; pim kinases; host; samhd1 ... See more keywords
HIV-2 Vpx neutralizes host restriction factor SAMHD1 to promote viral pathogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Scientific reports"
DOI: 10.1038/s41598-021-00415-2
Abstract: SAMHD1, a human host factor found in myeloid cells which restricts HIV-1 replication. It depletes the dNTPs pool for viral cDNA syntheses, thus preventing the viral replication in the cells. The viral accessory protein, Vpx,… read more here.
Keywords: samhd1; restriction factor; hiv; vpx ... See more keywords
The missing link: allostery and catalysis in the anti-viral protein SAMHD1
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Society Transactions"
DOI: 10.1042/bst20180348
Abstract: Vertebrate protein SAMHD1 (sterile-α-motif and HD domain containing protein 1) regulates the cellular dNTP (2′-deoxynucleoside-5′-triphosphate) pool by catalysing the hydrolysis of dNTP into 2′-deoxynucleoside and triphosphate products. As an important regulator of cell proliferation and… read more here.
Keywords: link allostery; samhd1; protein samhd1; missing link ... See more keywords
SAMHD1, positively regulated by KLF4, suppresses the proliferation of gastric cancer cells through MAPK p38 signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Cell Cycle"
DOI: 10.1080/15384101.2022.2085356
Abstract: ABSTRACT SAMHD1 was reported to be related with the development of tumors, while its function in gastric cancer (GC) has not been elucidated yet. Here, we investigated the role and mechanism of SAMHD1 in regulating… read more here.
Keywords: signaling pathway; proliferation; gastric cancer; mapk p38 ... See more keywords
dNTP depletion and beyond: the multifaceted nature of SAMHD1-mediated viral restriction
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Virology"
DOI: 10.1128/jvi.00302-25
Abstract: ABSTRACT SAMHD1 is a dNTPase of mammalian cells. In 2011, SAMHD1 was found to be a host restriction factor against retroviruses through dNTP reduction. Recent research provides evidence that the antiviral mechanisms of SAMHD1 cannot… read more here.
Keywords: samhd1 mediated; samhd1; dntp depletion; restriction ... See more keywords