Efficient pre-catalytic conformational change of reverse transcriptases from SAMHD1 non-counteracting primate lentiviruses during dNTP incorporation.
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DOI: 10.1016/j.virol.2019.08.010
Abstract: Unlike HIV-1, HIV-2 and some SIV strains replicate at high dNTP concentrations even in macrophages due to their accessory proteins, Vpx or Vpr, that target SAMHD1 dNTPase for proteasomal degradation. We previously reported that HIV-1… read more here.
Keywords: dntp; reverse; conformational change; samhd1 non ... See more keywords