Causal effect of renal function on venous thromboembolism: a two-sample Mendelian randomization investigation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-021-02494-4
Abstract: Whether renal function is causally associated with venous thromboembolism (VTE) is not yet fully elucidated. We conducted a two-sample Mendelian randomization (MR) study to determine the causal effect of renal function, measured as estimated glomerular… read more here.
Keywords: vte; two sample; venous thromboembolism; sample mendelian ... See more keywords
The Causality between Diabetes and Venous Thromboembolism: A Bidirectional Two-Sample Mendelian Randomization Study
Sign Up to like & getrecommendations! Published in 2022 at "Thrombosis and Haemostasis"
DOI: 10.1055/a-2040-4850
Abstract: BACKGROUND Diabetes was considered as a risk factor for venous thromboembolism (VTE), but conflicting findings have been reported from observational studies. This study aimed at investigating the causal associations of type 1 and type 2… read more here.
Keywords: two sample; sample mendelian; diabetes vte; venous thromboembolism ... See more keywords
ST2 and CSF‐1 as potential druggable targets of inflammatory bowel diseases: Results from two‐sample Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Science"
DOI: 10.1111/cts.13442
Abstract: Novel druggable targets are warranted for inflammatory bowel disease (IBD) treatment. We aimed to identify novel circulating proteins with causal associations with the risk of IBDs and provide potential therapeutic targets for IBD treatment. We… read more here.
Keywords: two sample; sample mendelian; mendelian randomization; inflammatory bowel ... See more keywords
Cannabis use and the risk of periodontitis: A two-sample Mendelian randomization study.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of clinical periodontology"
DOI: 10.1111/jcpe.13632
Abstract: AIM This study aimed to leverage human genetic data to investigate whether cannabis use causally affects periodontitis. METHODS AND MATERIALS Data were obtained from summary statistics of genome-wide association studies of lifetime cannabis use (N = 184,765),… read more here.
Keywords: two sample; sample mendelian; cannabis use; periodontitis ... See more keywords
Psychological factors as the risk factor of mouth ulcers: A two-sample Mendelian randomization study.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of health psychology"
DOI: 10.1177/1359105321999697
Abstract: To examine whether psychological traits (PT) had causal effects on Mouth Ulcers (MU), we applied two-sample Mendelian randomization (MR) to genetics association summary statistics of eleven PT and MU. After the adjustment of outlier variants,… read more here.
Keywords: mendelian randomization; two sample; psychological factors; sample mendelian ... See more keywords
Thyroid function and COVID-19 susceptibility and its severity: A Two-sample Mendelian randomization study.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrinology"
DOI: 10.1210/endocr/bqac139
Abstract: Several observational studies have confirmed the relationship between thyroid hormones and Coronavirus disease 2019 (COVID-19), but this correlation remains controversial. We performed a two-sample Mendelian Randomization (MR) analysis based on the public available largest summary… read more here.
Keywords: two sample; sample mendelian; mendelian randomization; covid ... See more keywords
The consequences of adjustment, correction and selection in genome-wide association studies used for two-sample Mendelian randomization
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DOI: 10.12688/wellcomeopenres.16752.1
Abstract: Introduction: Genome-wide association studies (GWASs) often adjust for covariates, correct for medication use, or select on medication users. If these summary statistics are used in two-sample Mendelian randomization analyses, estimates may be biased. We used… read more here.
Keywords: correction; mendelian randomization; two sample; randomization ... See more keywords
Connecting Genomics and Proteomics to Identify Protein Biomarkers for Adult and Youth-Onset Type 2 Diabetes: A Two-Sample Mendelian Randomization Study.
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DOI: 10.2337/db21-1046
Abstract: Type 2 diabetes shows an increasing prevalence in both adults and children. Identification of biomarkers for both youth and adult-onset type 2 diabetes is crucial for development of screening tools or drug targets. Here, using… read more here.
Keywords: two sample; onset type; sample mendelian; mendelian randomization ... See more keywords
Cancer and COVID-19 Susceptibility and Severity: A Two-Sample Mendelian Randomization and Bioinformatic Analysis
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DOI: 10.3389/fcell.2021.759257
Abstract: The clinical management of patients with COVID-19 and cancer is a Gordian knot that has been discussed widely but has not reached a consensus. We introduced two-sample Mendelian randomization to investigate the causal association between… read more here.
Keywords: cancer; covid; susceptibility; sample mendelian ... See more keywords
Blood Cells and Venous Thromboembolism Risk: A Two-Sample Mendelian Randomization Study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.919640
Abstract: Background Previous studies have shown that various cell indices are associated with a higher risk of venous thromboembolism (VTE), however, whether these findings reflect a causal relationship remains unclear. Therefore, we performed a two-sample Mendelian… read more here.
Keywords: two sample; cell; sample mendelian; mendelian randomization ... See more keywords
Constipation and cardiovascular disease: A two-sample Mendelian randomization analysis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2023.1080982
Abstract: Background Although several observational studies have suggested positive associations between constipation and cardiovascular disease (CVD), a solid causal association has not been demonstrated. Therefore, a two-sample Mendelian randomization (MR) study was performed to investigate the… read more here.
Keywords: two sample; sample mendelian; cardiovascular disease; disease ... See more keywords