Two‐Sample Mendelian Randomization Analyses Identified Lipid Species Associated With Intracranial Aneurysm Formation
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DOI: 10.1002/brb3.70435
Abstract: Intracranial aneurysm (IA) poses a significant health risk, and its formation involves various factors, including lipid metabolism, while former research only focused on the standard lipid. The purpose of this study is to explore 179… read more here.
Keywords: sample mendelian; aneurysm; mendelian randomization; intracranial aneurysm ... See more keywords
Anxiety disorder and cardiovascular disease: a two‐sample Mendelian randomization study
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DOI: 10.1002/ehf2.14676
Abstract: Cardiovascular disease is the leading cause of death worldwide. Anxiety disorders are common psychiatric conditions associated with cardiovascular outcomes. This two‐sample Mendelian randomization (MR) study investigated the causal relationship between anxiety disorders and coronary heart… read more here.
Keywords: sample mendelian; disease; cardiovascular disease; mendelian randomization ... See more keywords
Epilepsy and systemic autoimmune diseases: A bidirectional two‐sample Mendelian randomization study
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DOI: 10.1002/epi4.70102
Abstract: Epidemiological data indicates that individuals with epilepsy exhibit an elevated susceptibility to autoimmune disorders, and conversely, those with systemic autoimmune diseases (SAD) demonstrate a heightened predisposition to epilepsy. Although an increasing number of publications support… read more here.
Keywords: sample mendelian; bidirectional two; systemic autoimmune; autoimmune ... See more keywords
Causal effect of renal function on venous thromboembolism: a two-sample Mendelian randomization investigation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-021-02494-4
Abstract: Whether renal function is causally associated with venous thromboembolism (VTE) is not yet fully elucidated. We conducted a two-sample Mendelian randomization (MR) study to determine the causal effect of renal function, measured as estimated glomerular… read more here.
Keywords: vte; two sample; venous thromboembolism; sample mendelian ... See more keywords
Associations between gut microbiota and three prostate diseases: a bidirectional two-sample Mendelian randomization study
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DOI: 10.1038/s41598-024-54293-5
Abstract: According to previous observational researches and clinical trials, the gut microbiota is related to prostate diseases. However, the potential association between gut microbiota and prostate disorders is still uncertain. We first identified groups of gut… read more here.
Keywords: sample mendelian; prostate; gut microbiota; mendelian randomization ... See more keywords
The Causality between Diabetes and Venous Thromboembolism: A Bidirectional Two-Sample Mendelian Randomization Study
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DOI: 10.1055/a-2040-4850
Abstract: BACKGROUND Diabetes was considered as a risk factor for venous thromboembolism (VTE), but conflicting findings have been reported from observational studies. This study aimed at investigating the causal associations of type 1 and type 2… read more here.
Keywords: two sample; sample mendelian; diabetes vte; venous thromboembolism ... See more keywords
Identification of novel biomarkers for gastric adenocarcinoma through two-sample Mendelian randomization analysis of the human plasma proteome
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DOI: 10.1080/00365521.2025.2472198
Abstract: Abstract Background Papillary gastric adenocarcinoma (PGC), a histological subtype of gastric cancer (GC), is characterized by malignant potential and poor prognosis. Therefore, identifying novel biomarkers is urgently needed to enhance PGC diagnosis and treatment outcomes.… read more here.
Keywords: sample mendelian; plasma proteins; analysis; gastric adenocarcinoma ... See more keywords
Dietary antioxidants: a challenge or an opportunity for asthma? Genetic insights from a Two-sample mendelian randomization study
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DOI: 10.1080/02770903.2025.2555297
Abstract: Abstract Background Oxidative stress is crucial in the immune response and airway inflammatory process associated with asthma. While the relationship between dietary antioxidants and asthma remains debated in observational studies, this study uses two-sample Mendelian… read more here.
Keywords: sample mendelian; dietary antioxidants; mendelian randomization; two sample ... See more keywords
Genetic association between celiac disease and chronic kidney disease: a two-sample Mendelian randomization study
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DOI: 10.1080/0886022x.2024.2357246
Abstract: Abstract Objective A two-sample Mendelian randomization (MR) analysis was performed to elucidate the causal impact of celiac disease on the risk of chronic kidney disease (CKD). Methods The study comprised data from three genome-wide association… read more here.
Keywords: sample mendelian; disease; mendelian randomization; celiac disease ... See more keywords
The causality between C-reactive protein and asthma: a two-sample Mendelian randomization analysis.
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DOI: 10.1093/postmj/qgae019
Abstract: PURPOSE This study sought to investigate the causal effects of circulating C-reactive protein (CRP) level on risk of asthma and its subtypes by two-sample Mendelian randomization (MR) analysis. METHODS We utilized single nucleotide polymorphisms (SNPs)… read more here.
Keywords: sample mendelian; analysis; reactive protein; causality ... See more keywords
Investigation of the Association Between Hyperlipidemia and Ossification of the Posterior Longitudinal Ligament Through Two-Sample Mendelian Randomization Analysis
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DOI: 10.1097/brs.0000000000005208
Abstract: Study Design. A 2-sample Mendelian randomization (MR) analysis. Objective. This study aimed to investigate the association between genetically predicted hyperlipidemia and ossification of the posterior longitudinal ligament (OPLL) using a 2-sample MR analysis. Background. Several… read more here.
Keywords: sample mendelian; analysis; hyperlipidemia; association ... See more keywords