Isobaric labeling: Expanding the breadth, accuracy, depth, and diversity of sample multiplexing
Sign Up to like & getrecommendations! Published in 2022 at "PROTEOMICS"
DOI: 10.1002/pmic.202200328
Abstract: Isobaric labeling has rapidly become a predominant strategy for proteome‐wide abundance measurements. Coupled to mass spectrometry, sample multiplexing techniques using isobaric labeling are unparalleled for profiling proteins and posttranslational modifications across multiple samples in a… read more here.
Keywords: sample multiplexing; depth; accuracy; expanding breadth ... See more keywords
TMTpro-18plex: The Expanded and Complete Set of TMTpro Reagents for Sample Multiplexing.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.1c00168
Abstract: The development of the TMTpro-16plex series expanded the breadth of commercial isobaric tagging reagents by nearly 50% over classic TMT-11plex. In addition to the described 16plex reagents, the proline-based TMTpro molecule can accommodate two additional… read more here.
Keywords: complete set; expanded complete; sample multiplexing; 18plex expanded ... See more keywords
Profiling Yeast Deletion Strains Using Sample Multiplexing and Network-Based Analyses.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.2c00137
Abstract: The yeast, Saccharomyces cerevisiae, is a widely used model system for investigating conserved biological functions and pathways. Advancements in sample multiplexing have facilitated the study of the yeast proteome, yet many yeast proteins remain uncharacterized… read more here.
Keywords: sample multiplexing; network based; deletion; deletion strains ... See more keywords
Increased Throughput of Combined Stability Testing and Metabolite Identification Using a Sample Multiplexing Strategy for the Optimization of Engineered Cyclic Peptide Drugs.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Society for Mass Spectrometry"
DOI: 10.1021/jasms.5c00113
Abstract: Engineered cyclic peptides (ECPs) have been in the spotlight as novel drug modalities for challenging therapeutic targets. Oral delivery of engineered cyclic peptides benefits from ease of administration. However, one of the main hurdles in… read more here.
Keywords: stability; peptide drugs; engineered cyclic; multiplexing strategy ... See more keywords
Sample Multiplexing: Increased Throughput for Quantification of Total Testosterone in Serum by Liquid Chromatography-Tandem Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical chemistry"
DOI: 10.1093/clinchem/hvaa117
Abstract: BACKGROUND For high-volume assays, optimizing throughput reduces test cost and turn-around time. One approach for liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays is sample multiplexing, wherein the analyte of interest is derivatized in different specimens with… read more here.
Keywords: chromatography tandem; throughput; mass; sample multiplexing ... See more keywords
Abstract 1434: Advancing multiomic single-cell ATAC-seq assays by expanding scalability and flexibility using nuclear sample multiplexing and gentle sample preservation techniques
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-1434
Abstract: Recent advances in multiomic single-cell ATAC-seq assay development have enabled researchers to unravel complex biological questions by simultaneously profiling chromatin accessibility and gene expression in a single nucleus. One major challenge, however, remains in boosting… read more here.
Keywords: atac seq; sample; cell; flexibility ... See more keywords
Impact of sample multiplexing on detection of bacteria and antimicrobial resistance genes in pig microbiomes using long-read sequencing
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2025.1597804
Abstract: The effects of sample multiplexing on the detection sensitivity of antimicrobial resistance genes (ARGs) and pathogenic bacteria in metagenomic sequencing remain underexplored in newer sequencing technologies such as Oxford Nanopore Technologies (ONT), despite its critical… read more here.
Keywords: detection; multiplexing detection; resistance genes; antimicrobial resistance ... See more keywords