SapM mutation to improve the BCG vaccine: Genomic, transcriptomic and preclinical safety characterization.
Sign Up to like & getrecommendations! Published in 2019 at "Vaccine"
DOI: 10.1016/j.vaccine.2019.05.022
Abstract: The Mycobacterium bovis Bacille Calmette Guérin (BCG) vaccine shows variable efficacy in protection against adult tuberculosis (TB). Earlier, we have described a BCG mutant vaccine with a transposon insertion in the gene coding for the… read more here.
Keywords: bcg; bcg vaccine; sapm; live attenuated ... See more keywords
The SapM phosphatase can arrest phagosome maturation in an ESX-1 independent manner in Mycobacterium tuberculosis and BCG
Sign Up to like & getrecommendations! Published in 2024 at "Infection and Immunity"
DOI: 10.1128/iai.00217-24
Abstract: ABSTRACT Mycobacterium tuberculosis (Mtb) is an intracellular pathogen that survives and grows in macrophages. A mechanism used by Mtb to achieve intracellular survival is to secrete effector molecules that arrest the normal process of phagosome… read more here.
Keywords: bcg; pma; sapm; mtb ... See more keywords