New Insights on Saporin Resistance to Chemical Derivatization with Heterobifunctional Reagents
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DOI: 10.3390/biomedicines11041214
Abstract: Saporin is a type 1 ribosome-inactivating protein widely used as toxic payload in the construction of targeted toxins, chimeric molecules formed by a toxic portion linked to a carrier moiety. Among the most used carriers,… read more here.
Keywords: saporin; targeted toxins; heterobifunctional reagents; resistance ... See more keywords
Strategies to Improve the Clinical Utility of Saporin-Based Targeted Toxins
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DOI: 10.3390/toxins10020082
Abstract: Plant Ribosome-inactivating proteins (RIPs) including the type I RIP Saporin have been used for the construction of Immunotoxins (ITxs) obtained via chemical conjugation of the toxic domain to whole antibodies or by generating genetic fusions… read more here.
Keywords: saporin; improve clinical; clinical utility; saporin based ... See more keywords
Streptavidin-Saporin: Converting Biotinylated Materials into Targeted Toxins
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DOI: 10.3390/toxins15030181
Abstract: Streptavidin-Saporin can be considered a type of ‘secondary’ targeted toxin. The scientific community has taken advantage of this conjugate in clever and fruitful ways using many kinds of biotinylated targeting agents to send saporin into… read more here.
Keywords: saporin converting; saporin; targeted toxins; converting biotinylated ... See more keywords