Design, Synthesis, and SAR Studies of Heteroarylpyrimidines and Heteroaryltriazines as CB2R Ligands
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DOI: 10.1002/cmdc.201800541
Abstract: Herein we describe the design and synthesis of a new series of heteroarylpyrimidine/heteroaryltriazine derivatives on the basis of quinazoline‐2,4(1H,3H)‐diones as CB2R‐selective ligands using a bioisosterism strategy. An acetamide group was explored to displace the enamine… read more here.
Keywords: design synthesis; synthesis sar; activity; sar studies ... See more keywords
Synthesis and SAR studies of novel isoquinoline and tetrahydroisoquinoline derivatives as melatonin receptor ligands.
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DOI: 10.1002/cmdc.202100658
Abstract: In our constant search for new successors of Agomelatine, we report herein another new series of compounds resulting from bio-isosteric modulation of the naphthalene ring. New isoquinoline and tetrahydroisoquinoline derivatives were synthesized and pharmacologically evaluated.… read more here.
Keywords: sar studies; studies novel; synthesis sar; tetrahydroisoquinoline derivatives ... See more keywords
A comparative account of sar studies of semicarbazones and thiosemicarbazones on cathepsins H and L
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-1826-9
Abstract: Cathepsins H and L, lysosomal cysteine proteases have been found in elevated levels in tumor invasion, metastasis, inflammation, atherosclerosis, and various other tissue degenerative diseases. In the past decade, work has largely been focused on… read more here.
Keywords: sar studies; semicarbazones thiosemicarbazones; comparative account; account sar ... See more keywords
Isoxazole derivatives as anticancer agent: A review on synthetic strategies, mechanism of action and SAR studies.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113511
Abstract: Breast cancer is the second most leading cause of death among women. Multiple drugs have been approved by FDA for the treatment of BC. The major drawbacks of existing drugs are the development of resistance,… read more here.
Keywords: sar studies; isoxazole derivatives; anticancer agent; inhibition ... See more keywords
Cytotoxic Alkylynols of the Sponge Cribrochalina vasculum: Structure, Synthetic Analogs and SAR Studies
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DOI: 10.3390/md20040265
Abstract: A series of twenty-three linear and branched chain mono acetylene lipids were isolated from the Caribbean Sea sponge Cribrochalina vasculum. Seventeen of the compounds, 1–17, are new, while six, 18–23, were previously characterized from the… read more here.
Keywords: cribrochalina vasculum; sponge cribrochalina; rac rac; rac ... See more keywords
Molecular Docking Q-SAR Studies of Benzimidazole as Antifungal Nucleus
Sign Up to like & getrecommendations! Published in 2021 at "Research Journal of Pharmacy and Technology"
DOI: 10.52711/0974-360x.2021.00388
Abstract: Benzimidazole and its derivatives are used in organic synthesis and vermicides or fungicides as they inhibit the action of certain microorganisms. The molecules to be analysed were aligned on an appropriate template, which is considered… read more here.
Keywords: sar studies; benzimidazole antifungal; molecular docking; studies benzimidazole ... See more keywords