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   Articles with "sar studies" as a keyword



Synthetic Strategies and SAR Studies of Triazine‐Based Antiepileptic Agents: A Bench to Bedside Approach

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recommendations! Published in 2025 at "Archiv der Pharmazie"

DOI: 10.1002/ardp.202500087

Abstract: Due to their strong biological activity, heterocyclic compounds containing triazine scaffolds are now of interest to a large number of organic chemists. It has been discovered that the triazine ring possesses antiepileptic properties. The article's… read more here.

Keywords: sar studies; studies triazine; triazine based; sodium channel ... See more keywords

Design, Synthesis, and SAR Studies of Heteroarylpyrimidines and Heteroaryltriazines as CB2R Ligands

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recommendations! Published in 2018 at "ChemMedChem"

DOI: 10.1002/cmdc.201800541

Abstract: Herein we describe the design and synthesis of a new series of heteroarylpyrimidine/heteroaryltriazine derivatives on the basis of quinazoline‐2,4(1H,3H)‐diones as CB2R‐selective ligands using a bioisosterism strategy. An acetamide group was explored to displace the enamine… read more here.

Keywords: design synthesis; synthesis sar; activity; sar studies ... See more keywords
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Synthesis and SAR studies of novel isoquinoline and tetrahydroisoquinoline derivatives as melatonin receptor ligands.

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recommendations! Published in 2021 at "ChemMedChem"

DOI: 10.1002/cmdc.202100658

Abstract: In our constant search for new successors of Agomelatine, we report herein another new series of compounds resulting from bio-isosteric modulation of the naphthalene ring. New isoquinoline and tetrahydroisoquinoline derivatives were synthesized and pharmacologically evaluated.… read more here.

Keywords: sar studies; studies novel; synthesis sar; tetrahydroisoquinoline derivatives ... See more keywords
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A comparative account of sar studies of semicarbazones and thiosemicarbazones on cathepsins H and L

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recommendations! Published in 2017 at "Medicinal Chemistry Research"

DOI: 10.1007/s00044-017-1826-9

Abstract: Cathepsins H and L, lysosomal cysteine proteases have been found in elevated levels in tumor invasion, metastasis, inflammation, atherosclerosis, and various other tissue degenerative diseases. In the past decade, work has largely been focused on… read more here.

Keywords: sar studies; semicarbazones thiosemicarbazones; comparative account; account sar ... See more keywords

Development of semisynthetic saponin immunostimulants

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recommendations! Published in 2024 at "Medicinal Chemistry Research"

DOI: 10.1007/s00044-024-03227-x

Abstract: Many natural saponins demonstrate immunostimulatory adjuvant activities, but they also have some inherent drawbacks that limit their clinical use. To overcome these limitations, extensive structure-activity-relationship (SAR) studies have been conducted. The SAR studies of QS-21… read more here.

Keywords: sar studies; saponin immunostimulants; side chain; semisynthetic saponin ... See more keywords

Isoxazole derivatives as anticancer agent: A review on synthetic strategies, mechanism of action and SAR studies.

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recommendations! Published in 2021 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2021.113511

Abstract: Breast cancer is the second most leading cause of death among women. Multiple drugs have been approved by FDA for the treatment of BC. The major drawbacks of existing drugs are the development of resistance,… read more here.

Keywords: sar studies; isoxazole derivatives; anticancer agent; inhibition ... See more keywords

Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-023-44376-8

Abstract: Avapritinib is the only potent and selective inhibitor approved for the treatment of D842V-mutant gastrointestinal stromal tumors (GIST), the most common primary mutation of the platelet-derived growth factor receptor α (PDGFRA). The approval was based… read more here.

Keywords: sar studies; avapritinib based; pocket; pdgfra ... See more keywords

Cytotoxic Alkylynols of the Sponge Cribrochalina vasculum: Structure, Synthetic Analogs and SAR Studies

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recommendations! Published in 2022 at "Marine Drugs"

DOI: 10.3390/md20040265

Abstract: A series of twenty-three linear and branched chain mono acetylene lipids were isolated from the Caribbean Sea sponge Cribrochalina vasculum. Seventeen of the compounds, 1–17, are new, while six, 18–23, were previously characterized from the… read more here.

Keywords: cribrochalina vasculum; sponge cribrochalina; rac rac; rac ... See more keywords

Molecular Docking Q-SAR Studies of Benzimidazole as Antifungal Nucleus

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recommendations! Published in 2021 at "Research Journal of Pharmacy and Technology"

DOI: 10.52711/0974-360x.2021.00388

Abstract: Benzimidazole and its derivatives are used in organic synthesis and vermicides or fungicides as they inhibit the action of certain microorganisms. The molecules to be analysed were aligned on an appropriate template, which is considered… read more here.

Keywords: sar studies; benzimidazole antifungal; molecular docking; studies benzimidazole ... See more keywords