The Effects of the Alkaloid Tambjamine J on Mice Implanted with Sarcoma 180 Tumor Cells
Sign Up to like & getrecommendations! Published in 2020 at "ChemMedChem"
DOI: 10.1002/cmdc.202000387
Abstract: The tambjamines are a small group of bipyrrolic alkaloids that, collectively, display a significant range of biological activities including antitumor, antimicrobial and immunosuppressive properties. The key objective of the present study was to undertake preclinical… read more here.
Keywords: effects alkaloid; sarcoma 180; alkaloid tambjamine; tambjamine mice ... See more keywords
Antitumour, acute toxicity and molecular modeling studies of 4-(pyridin-4-yl)-6-(thiophen-2-yl) pyrimidin-2(1H)-one against Ehrlich ascites carcinoma and sarcoma-180
Sign Up to like & getrecommendations! Published in 2018 at "Heliyon"
DOI: 10.1016/j.heliyon.2018.e00661
Abstract: In an effort to discover an effective and selective antitumour agent, synthesis and anti-cancer potential of 4-(pyridin-4-yl)-6-(thiophen-2-yl) pyrimidin-2(1H)-one (SK-25), which has been reported earlier by us with significant cytotoxicity towards MiaPaCa-2 malignant cells, with an… read more here.
Keywords: ascites carcinoma; sarcoma 180; pyridin thiophen; thiophen pyrimidin ... See more keywords
α-Phellandrene exhibits antinociceptive and tumor-reducing effects in a mouse model of oncologic pain.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2021.115497
Abstract: Medical reports indicate a prevalence of pain in 50% of patients with cancer. In this context, this article investigated the antinociceptive activity of α-PHE using in vivo Sarcoma-180-induced hypernociception in mice to detail its mechanism(s)… read more here.
Keywords: phellandrene exhibits; sarcoma 180; model; phe ... See more keywords
Enhanced antitumor efficacy of poly(D,L-lactide-co-glycolide)-based methotrexate-loaded implants on sarcoma 180 tumor-bearing mice
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DOI: 10.2147/dddt.s143942
Abstract: Purpose Methotrexate is widely used in chemotherapy for a variety of malignancies. However, severe toxicity, poor pharmacokinetics, and narrow safety margin of methotrexate limit its clinical application. The aim of this study was to develop… read more here.
Keywords: tumor; methotrexate; sarcoma 180; loaded implants ... See more keywords
Antitumor Profile of Combined Matricaria recutita Flower Extract and 5-Fluorouracil Chemotherapy in Sarcoma 180 In Vivo Model
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DOI: 10.3390/toxics11040375
Abstract: Medicinal plants have been commonly associated with chemotherapeutic treatments, as an approach to reduce the toxicological risks of classical anticancer drugs. The objective of this study was to evaluate the effects of combining the antineoplastic… read more here.
Keywords: day; sarcoma 180; mrfe 200; matricaria recutita ... See more keywords