Systematic analysis of Kaposi's sarcoma (KS)‐associated herpesvirus genomes from a KS case‐control study in Cameroon: Evidence of dual infections but no association between viral sequence variation and KS risk
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DOI: 10.1002/ijc.34136
Abstract: In sub‐Saharan Africa, Kaposi's sarcoma‐associated herpesvirus (KSHV) is endemic, and Kaposi's sarcoma (KS) is a significant public health problem. Until recently, KSHV genotype analysis was performed using variable gene regions, representing a small fraction of… read more here.
Keywords: control; sequence; kaposi sarcoma; analysis ... See more keywords
Social behavioral correlates of Kaposi sarcoma–associated herpesvirus infection among Han and Uygur populations in Xinjiang, China
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DOI: 10.1002/jmv.25332
Abstract: Kaposi sarcoma–associated herpesvirus (KSHV) is endemic in Xinjiang, China and its prevalence varies considerably across ethnic groups. The current study explored the prevalence and correlates of KSHV infection among Han and Uygur populations in Xinjiang. read more here.
Keywords: kaposi sarcoma; infection among; among han; xinjiang china ... See more keywords
Human leukocyte antigen polymorphisms and Kaposi's sarcoma‐associated herpesvirus infection outcomes: A call for deeper exploration
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DOI: 10.1002/jmv.25342
Abstract: Host genetic background may influence the immunity to resist viral infection. As the most polymorphic loci in the entire human genome, the human leukocyte antigen (HLA) system plays an important role in innate and adaptive… read more here.
Keywords: kaposi sarcoma; infection; human leukocyte; associated herpesvirus ... See more keywords
Lipids, lipid metabolism and Kaposi’s sarcoma-associated herpesvirus pathogenesis
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DOI: 10.1007/s12250-017-4027-2
Abstract: AbstractLipids are essential for mammalian cells to maintain many physiological functions. Emerging evidence has shown that cancer cells can develop specific alterations in lipid biosynthesis and metabolism to facilitate their survival and various malignant behaviors.… read more here.
Keywords: lipids lipid; metabolism; kaposi sarcoma; pathogenesis ... See more keywords
Transcriptional and Post-Transcriptional Regulation of Viral Gene Expression in the Gamma-Herpesvirus Kaposi’s Sarcoma-Associated Herpesvirus
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DOI: 10.1007/s40588-018-0102-1
Abstract: Purpose of ReviewKaposi’s sarcoma-associated herpesvirus (KSHV), the etiological agent of the AIDS-associated tumor Kaposi’s sarcoma, is a complex virus that expresses ~ 90 proteins in a regulated temporal cascade during its replication cycle. Although KSHV relies… read more here.
Keywords: gene expression; gene; herpesvirus; sarcoma associated ... See more keywords
Runaway Kaposi Sarcoma-associated herpesvirus replication correlates with systemic IL-10 levels.
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DOI: 10.1016/j.virol.2019.10.002
Abstract: KSHV-associated inflammatory cytokine syndrome (KICS) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV). KICS is associated with high-level, systemic replication of KSHV. This study characterized the clinical and virologic features of a KICS patient over time.… read more here.
Keywords: sarcoma; kaposi sarcoma; kshv; associated herpesvirus ... See more keywords
Homology-directed repair in mouse cells increased by CasRx-mediated knockdown or co-expressing Kaposi’s sarcoma-associated herpesvirus ORF52
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DOI: 10.1042/bsr20191914
Abstract: Abstract Precise genome editing with directed base insertion or targeted point mutations can be achieved by CRISPR/Cas9-mediated homology-directed repair (HDR) and is of great significance in clinical disease therapy. However, HDR efficiency, compared with non-homologous… read more here.
Keywords: sarcoma associated; kaposi sarcoma; associated herpesvirus; directed repair ... See more keywords
Kaposi's sarcoma–associated herpesvirus replication and transcription activator protein activates CD274/PD‐L1 gene promoter
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DOI: 10.1111/cas.15673
Abstract: Kaposi's sarcoma–associated herpesvirus (KSHV) is responsible for the pathogenesis of Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman disease. The expression of immunosuppressive genes, such as IL‐10 and CD274/PD‐L1 is observed during KSHV‐associated pathogenesis, and… read more here.
Keywords: promoter; kaposi sarcoma; associated herpesvirus; cd274 gene ... See more keywords
C19ORF66 Broadly Escapes Virus-Induced Endonuclease Cleavage and Restricts Kaposi’s Sarcoma-Associated Herpesvirus
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DOI: 10.1128/jvi.00373-19
Abstract: Viruses are master regulators of the host gene expression machinery. This is crucial to promote viral infection and to dampen host immune responses. Many viruses, including herpesviruses, express RNases that reduce host gene expression through… read more here.
Keywords: viral infection; sarcoma associated; kaposi sarcoma; infection ... See more keywords
Conserved CxnC Motifs in Kaposi’s Sarcoma-Associated Herpesvirus ORF66 Are Required for Viral Late Gene Expression and Are Essential for Its Interaction with ORF34
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DOI: 10.1128/jvi.01299-19
Abstract: Kaposi’s sarcoma-associated herpesvirus (KSHV; human herpesvirus 8) is an oncogenic gammaherpesvirus that is the causative agent of multiple human cancers. The release of infectious virions requires the production of capsid proteins and other late genes,… read more here.
Keywords: sarcoma associated; late gene; kaposi sarcoma; associated herpesvirus ... See more keywords
Upregulation of ATF4-LAMP3 Axis by ORF45 Facilitates Lytic Replication of Kaposi’s Sarcoma-Associated Herpesvirus
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DOI: 10.1128/jvi.01456-22
Abstract: The lytic replication of Kaposi’s sarcoma-associated herpesvirus (KSHV) reprograms cellular transcription and translation to generate viral proteins and virion particles. Here, we show that the mediator of ER stress ATF4 and the expression of the… read more here.
Keywords: lytic replication; replication; lamp3; kaposi sarcoma ... See more keywords