Genomic and phenotypic stability of fusion-driven pediatric sarcoma cell lines
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-024-55340-5
Abstract: Human cancer cell lines are the mainstay of cancer research. Recent reports showed that highly mutated adult carcinoma cell lines (mainly HeLa and MCF-7) present striking diversity across laboratories and that long-term continuous culturing results… read more here.
Keywords: cell lines; sarcoma cell; pediatric sarcoma; culture ... See more keywords
Sarcoma cell-specific radiation sensitization by titanate scrolled nanosheets: insights from physicochemical analysis and transcriptomic profiling
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-53847-x
Abstract: This study aimed to explore the potential of metal oxides such as Titanate Scrolled Nanosheets (TNs) in improving the radiosensitivity of sarcoma cell lines. Enhancing the response of cancer cells to radiation therapy is crucial,… read more here.
Keywords: sarcoma cell; radiation; analysis; cell ... See more keywords
Abstract B61: Intratumoral oxygen gradients mediate sarcoma cell invasion
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.epso16-b61
Abstract: Hypoxia is a critical factor in the progression and metastasis of many cancers including soft tissue sarcomas. Frequently, oxygen (O2) gradients develop in tumors as they grow beyond their vascular supply leading to heterogeneous areas… read more here.
Keywords: invasion; sarcoma cell; cell invasion; oxygen gradients ... See more keywords
Abstract B28: A cross-species enhancer activity analysis approach to identify the Ewing sarcoma cell of origin
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.pedca19-b28
Abstract: Ewing sarcoma is a malignant bone and soft tissue tumor in children and adolescents. In 85% of all cases the formation of Ewing sarcoma is caused by a chromosomal translocation, leading to the expression of… read more here.
Keywords: cross species; sarcoma cell; cell origin; ewing sarcoma ... See more keywords
A novel canine histiocytic sarcoma cell line: initial characterization and utilization for drug screening studies
Sign Up to like & getrecommendations! Published in 2018 at "BMC Cancer"
DOI: 10.1186/s12885-018-4132-0
Abstract: BackgroundHistiocytic sarcoma is a rare disorder in humans, however it is seen with appreciable frequency in certain breeds of dogs, such as Bernese mountain dog. The purpose of this study was to fully characterize a… read more here.
Keywords: sarcoma cell; cell; cell line; histiocytic sarcoma ... See more keywords
Establishment and characterization of 18 Sarcoma Cell Lines: Unraveling the Molecular Mechanisms of Doxorubicin Resistance in Sarcoma Cell Lines
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-024-05700-y
Abstract: Sarcomas, malignant tumors from mesenchymal tissues, exhibit poor prognosis despite advancements in treatment modalities such as surgery, radiotherapy, and chemotherapy, with doxorubicin being a cornerstone treatment. Resistance to doxorubicin remains a significant hurdle in therapy… read more here.
Keywords: cell; cell lines; doxorubicin resistance; sarcoma cell ... See more keywords
Heterogeneity in sarcoma cell lines reveals enhanced motility of tetraploid versus diploid cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14291
Abstract: Soft tissue sarcomas with complex genomics are very heterogeneous tumors lacking simple prognosis markers or targeted therapies. Overexpression of a subset of mitotic genes from a signature called CINSARC is of bad prognosis, but the… read more here.
Keywords: cell lines; sarcoma cell; tetraploid; cell ... See more keywords
The Effect of Lurbinectedin as a Monotherapy and in Combination with Ionizing Radiation on Sarcoma Cell Lines
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DOI: 10.3390/cancers17172930
Abstract: Simple Summary Soft tissue sarcoma is a rare and heterogeneous group of tumors. Especially when metastasized, the treatment options remain limited. Therefore, this study evaluates the potential of Lurbinectedin, a chemotherapeutic agent, for the treatment… read more here.
Keywords: treatment; cell lines; sarcoma cell; cell ... See more keywords
5-Aminolevrinic Acid Exhibits Dual Effects on Stemness in Human Sarcoma Cell Lines under Dark Conditions
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076189
Abstract: 5-aminolevulinic acid (ALA) is used for tumor-targeting phototherapy because it is converted to protoporphyrin IX (PPIX) upon excitation and induces phototoxicity. However, the effect of ALA on malignant cells under unexcited conditions is unclear. This… read more here.
Keywords: cell; ala; sphere forming; sarcoma cell ... See more keywords