Targeted inactivation of EWSR1 : : FLI1 gene in Ewing sarcoma via CRISPR/Cas9 driven by an Ewing-specific GGAA promoter
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DOI: 10.1038/s41417-025-00887-8
Abstract: We have recently demonstrated that genetic inactivation of EWSR1 : : FLI1 by CRISPR/Cas9, successfully blocks cell proliferation in a cell model of Ewing sarcoma. However, CRISPR/Cas9-mediated gene editing can exhibit off-target effects, and thus, precise… read more here.
Keywords: ewsr1 fli1; ewing sarcoma; sarcoma cells; gene ... See more keywords
PO-008 Anti-tumour properties of novel multikinase inhibitors in sarcomas: synergistic combination with doxorubicin
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.543
Abstract: Introduction Cytotoxic drugs like doxorubicin remain as the most utilised agents in sarcoma treatment. However, advanced sarcomas often show resistance to these drugs, mainly through the overexpression of members of the ATP binding cassette (ABC)… read more here.
Keywords: multikinase inhibitors; drug; effect; anti tumour ... See more keywords
Abstract 3532: Activator protein-1 (AP-1) signaling inhibits the growth of Ewing sarcoma cells in response to DNA replication stress
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DOI: 10.1158/1538-7445.am2023-3532
Abstract: Ribonucleotide reductase (RNR) is the rate-limiting enzyme in the synthesis of deoxyribonucleoside triphosphates (dNTPs) and is required for DNA replication and the repair of DNA damage. Multiple types of cancer, including Ewing sarcoma tumors, are… read more here.
Keywords: sarcoma; ewing sarcoma; activator protein; sarcoma cells ... See more keywords
Abstract 3652: Circular RNAs repress interferon responses in the sarcoma cells and promote sarcoma growth by forging a pro-tumorigenic immune microenvironment
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DOI: 10.1158/1538-7445.am2023-3652
Abstract: Circular RNAs (CircRNA) arise from events of non-conventional splicing in which the 3'-tail of an exon back-splices and joins the 5'-head of the upstream exon. Because of their structural conformation, these RNAs are incredibly stable… read more here.
Keywords: pro tumorigenic; promote sarcoma; sarcoma growth; circular rnas ... See more keywords
Abstract A016 EWSR1 in Ewing sarcoma cells exhibits enhanced recruitment to sites of active transcription compared to that observed in non-Ewing sarcoma cells
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DOI: 10.1158/1538-7445.pediatric24-a016
Abstract: The initiating genetic event in several pediatric tumor-types, including Ewing sarcoma (EWS), involve translocations affecting the EWSR1 locus. The EWSR1 gene encodes EWSR1, a transcriptional regulator. In EWS cells expressing the fusion oncoprotein EWSR1::FLI1, studies… read more here.
Keywords: ewsr1 fli1; ewing sarcoma; ews cells; sarcoma cells ... See more keywords
USP6 Confers Sensitivity to IFN-Mediated Apoptosis through Modulation of TRAIL Signaling in Ewing Sarcoma
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DOI: 10.1158/1541-7786.mcr-18-0289
Abstract: Ewing sarcoma is the second most common sarcoma of the bone, afflicting predominantly the pediatric population. Although patients with localized disease exhibit favorable survival rates, patients with metastatic disease suffer a dismal 5-year rate of… read more here.
Keywords: sarcoma; trail; ewing sarcoma; sarcoma usp6 ... See more keywords
Eltrombopag inhibits the proliferation of Ewing sarcoma cells via iron chelation and impaired DNA replication
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DOI: 10.1186/s12885-020-07668-6
Abstract: Background The treatment of Ewing sarcoma, an aggressive bone and soft tissue sarcoma, is associated with suboptimal outcomes and significant side-effects. Consequently, there is an urgent need to identify novel therapies that will improve outcomes… read more here.
Keywords: sarcoma; dna replication; ewing sarcoma; cell ... See more keywords
AT-hook DNA-binding motif-containing protein one knockdown downregulates EWS-FLI1 transcriptional activity in Ewing’s sarcoma cells
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DOI: 10.1371/journal.pone.0269077
Abstract: Ewing’s sarcoma is the second most common bone malignancy in children or young adults and is caused by an oncogenic transcription factor by a chromosomal translocation between the EWSR1 gene and the ETS transcription factor… read more here.
Keywords: transcriptional activity; ewing sarcoma; knockdown; sarcoma cells ... See more keywords
Ibuprofen on Proliferation and Apoptosis of Sarcoma Cells via PI3K/Akt/mTOR Signaling Pathway.
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DOI: 10.14715/cmb/2021.67.5.10
Abstract: Nowadays, there is a serious lack of information about the value-added apoptosis of sarcoma cells in China. Especially in clinical medicine, exploring the effect of ibuprofen on the growth and apoptosis of fibrosarcoma cells under… read more here.
Keywords: pi3k akt; apoptosis; mtor signaling; akt mtor ... See more keywords
Inhibition of CHK1 sensitizes Ewing sarcoma cells to the ribonucleotide reductase inhibitor gemcitabine
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DOI: 10.18632/oncotarget.18776
Abstract: Ewing sarcoma is a bone and soft tissue sarcoma that occurs in children and young adults. The EWS-FLI1 gene fusion is the driver mutation in most Ewing sarcoma tumors and functions, in part, as an… read more here.
Keywords: sarcoma; chk1; inhibitor; inhibition ... See more keywords
Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.25760
Abstract: Ewing sarcoma (EwS) is an aggressive pediatric bone cancer in need of more effective therapies than currently available. Most research into novel targeted therapeutic approaches is focused on the fusion oncogene EWSR1-FLI1, which is the… read more here.
Keywords: ews fli1; differential sensitivities; ewing sarcoma; sensitivities ewing ... See more keywords