Diagnostic and therapeutic management of sarcoma patients
Sign Up to like & getrecommendations! Published in 2020 at "memo - Magazine of European Medical Oncology"
DOI: 10.1007/s12254-020-00601-4
Abstract: In this special issue of the Magazine of EuropeanMedical Oncology (MEMO) clinical experts are summarizing the most relevant topics regarding the management and treatment of sarcoma patients. Collectively, their message is clear—a centralized multidisciplinary tumour… read more here.
Keywords: therapeutic management; oncology; diagnostic therapeutic; sarcoma patients ... See more keywords
OX40 and 4-1BB delineate distinct immune profiles in sarcoma
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2022.2066050
Abstract: ABSTRACT Systemic relapse after radiotherapy and surgery is the major cause of disease-related mortality in sarcoma patients. Combining radiotherapy and immunotherapy is under investigation as a means to improve response rates. However, the immune contexture… read more here.
Keywords: immune profiles; 1bb tnfrsf9; sarcoma; sarcoma patients ... See more keywords
Improved survival using specialized multidisciplinary board in sarcoma patients
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DOI: 10.1093/annonc/mdx484
Abstract: Background Sarcomas are rare but aggressive diseases. Specialized multidisciplinary management is not implemented for all patients in most countries. We investigated the impact of a multidisciplinary tumor board (MDTB) presentation before treatment in a nationwide… read more here.
Keywords: sarcoma; treatment; specialized multidisciplinary; board ... See more keywords
1106 Timing of Free Flap Reconstruction in Sarcoma Patients
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Surgery"
DOI: 10.1093/bjs/znab259.719
Abstract: In 1986 Godina reported that microsurgical reconstruction of traumatic wounds in the extremities undertaken with >72-hour delay caused significant tissue damage, hampering the microsurgical reconstruction and significantly increasing complication rates. It is our opinion that… read more here.
Keywords: reconstruction; sarcoma; free flap; extremity ... See more keywords
Abstract 4578: Miniaturized and multiplexed evaluation of NK cell cytotoxicity and infiltration in patient-derived sarcoma spheroids using a novel multichambered microwell chip
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4578
Abstract: Tumor diversity and rarity of patient tumor material negatively contribute to the development of new effective treatments for sarcomas. As a high proportion of sarcoma patients presents inherent or acquired chemo-resistance, immune checkpoint inhibitors could… read more here.
Keywords: cell; sarcoma spheroids; patient; sarcoma patients ... See more keywords
Survival and signals of response in advanced sarcoma patients enrolled on phase 1 trials in the era of precision oncology and novel immunotherapies.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.11063
Abstract: 11063 Background: Few effective US FDA approved therapies exist for refractory, metastatic sarcomas. Many of these patients therefore enroll onto phase 1 clinical trials. Because tumor-specific outcomes are not always reported in less common cancers… read more here.
Keywords: sarcoma; response; novel immunotherapies; sarcoma patients ... See more keywords
Association of immune-related adverse events (irAEs) with improved clinical outcome in sarcoma patients treated with immune checkpoint blockade (ICB).
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.11510
Abstract: 11510Background: IrAEs are associated with improved clinical outcomes after treatment with ICB in select epithelial malignancies. We hypothesized that sarcoma patients (pts) treated with ICB who de... read more here.
Keywords: icb; immune related; improved clinical; related adverse ... See more keywords
A Simple Prognostic Benefit Scoring System for Sarcoma Patients with Pulmonary Metastases: Sarcoma Lung Metastasis Score
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Surgical Oncology"
DOI: 10.1245/s10434-020-09272-1
Abstract: Pulmonary metastasectomy could be considered one of the treatment options for disease control in sarcoma patients with pulmonary metastases; however, there is little consensus regarding the suitable criteria for predicting the likely outcomes in these… read more here.
Keywords: pulmonary metastases; lung metastasis; patients pulmonary; score ... See more keywords
Retinoic Acid Metabolism-Related Enzyme Signature Identified Prognostic and Immune Characteristics in Sarcoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.780951
Abstract: Growing evidence indicates a link between retinoic acid (RA) metabolism and sarcoma progression or immunity in laboratory studies. However, a comprehensive analysis of RA abnormality in the sarcoma population is still lacking. Herein, we systematically… read more here.
Keywords: metabolism; acid metabolism; metabolism related; retinoic acid ... See more keywords
Unmet Medical Needs and Future Perspectives for Leiomyosarcoma Patients—A Position Paper from the National LeioMyoSarcoma Foundation (NLMSF) and Sarcoma Patients EuroNet (SPAEN)
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DOI: 10.3390/cancers13040886
Abstract: Simple Summary In this position paper, we aim to summarize state-of-the-art treatments for patients with leiomyosarcomas in order to identify knowledge gaps and current unmet needs, thereby guiding the community to design innovative clinical trials… read more here.
Keywords: research; paper; position paper; sarcoma patients ... See more keywords
Immunologic Gene Signature Analysis Correlates Myeloid Cells and M2 Macrophages with Time to Trabectedin Failure in Sarcoma Patients
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DOI: 10.3390/cancers14051290
Abstract: Simple Summary Trabectedin is an FDA-approved chemotherapy with demonstrated benefit for some sarcoma subtypes, particularly in the metastatic setting. Although some patients receiving trabectedin have only modest benefit, other patients are exceptional responders. While several… read more here.
Keywords: analysis; expression; immunologic gene; gene ... See more keywords