A Contraction Stress Model of Hypertrophic Cardiomyopathy due to Sarcomere Mutations
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DOI: 10.1016/j.stemcr.2018.11.015
Abstract: Summary Thick-filament sarcomere mutations are a common cause of hypertrophic cardiomyopathy (HCM), a disorder of heart muscle thickening associated with sudden cardiac death and heart failure, with unclear mechanisms. We engineered four isogenic induced pluripotent… read more here.
Keywords: hypertrophic cardiomyopathy; stress; sarcomere mutations; stress model ... See more keywords