Sarcoplasmic reticulum calcium mishandling: central tenet in heart failure?
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical Reviews"
DOI: 10.1007/s12551-020-00736-y
Abstract: Excitation-contraction coupling links excitation of the sarcolemmal surface membrane to mechanical contraction. In the heart this link is established via a Ca2+-induced Ca2+ release process, which, following sarcolemmal depolarisation, prompts Ca2+ release from the sarcoplasmic… read more here.
Keywords: heart; sarcoplasmic reticulum; ca2; heart failure ... See more keywords
Geographic Plasmodium falciparum sarcoplasmic reticulum Ca2+ ATPase (PfSERCA) genotype diversity in India.
Sign Up to like & getrecommendations! Published in 2019 at "Acta tropica"
DOI: 10.1016/j.actatropica.2019.105095
Abstract: Plasmodium falciparum sarcoplasmic reticulum Ca2+ ATPase (PfSERCA) is sarcoplasmic reticulum membrane bound transporter to regulate cytosol Ca2+ ions. Ca2+ act as secondary messenger and play important role in differentiation of parasite during its life cycle.… read more here.
Keywords: pfserca; plasmodium falciparum; sarcoplasmic reticulum; diversity ... See more keywords
Human Cardiac Fibroblasts Engage the Sarcoplasmic Reticulum in Induced Pluripotent Stem Cell-Derived Cardiomyocyte Excitation-Contraction Coupling.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2018.06.028
Abstract: Ca2+-induced Ca2+ release (CICR), the process whereby a small influx of Ca2+ across the sarcolemma triggers a significantly larger Ca2+ release from the sarcoplasmic reticulum (SR), is at the heart of efficient cardiac excitation–contraction coupling… read more here.
Keywords: excitation contraction; sarcoplasmic reticulum; contraction coupling;
The dynamics of Ca2+ within the sarcoplasmic reticulum of frog skeletal muscle. A simulation study.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2020.110371
Abstract: In skeletal muscle, Ca2+ release from the sarcoplasmic reticulum (SR) triggers contraction. In this study we develop a two compartment model to account for the Ca2+ dynamics in frog skeletal muscle fibers. The two compartments… read more here.
Keywords: skeletal muscle; frog skeletal; sarcoplasmic reticulum; ca2 ... See more keywords
Reduced sarcoplasmic reticulum Ca2+ ATPase activity underlies skeletal muscle wasting in asthma.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119296
Abstract: AIMS Skeletal muscle mass and strength are reduced in asthma and contribute to compromised functional capacity in asthmatic patients. However, an effective pharmacological intervention remains elusive, partly because molecular mechanisms dictating muscle decline in asthma… read more here.
Keywords: skeletal muscle; muscle; reticulum ca2; sarcoplasmic reticulum ... See more keywords
CMYA5 establishes cardiac dyad architecture and positioning.
Sign Up to like & getrecommendations! Published in 2022 at "Nature communications"
DOI: 10.1038/s41467-022-29902-4
Abstract: Cardiac excitation-contraction coupling requires dyads, the nanoscopic microdomains formed adjacent to Z-lines by apposition of transverse tubules and junctional sarcoplasmic reticulum. Disruption of dyad architecture and function are common features of diseased cardiomyocytes. However, little… read more here.
Keywords: sarcoplasmic reticulum; architecture; junctional sarcoplasmic; dyad architecture ... See more keywords
Microtubule structures underlying the sarcoplasmic reticulum support peripheral coupling sites to regulate smooth muscle contractility
Sign Up to like & getrecommendations! Published in 2017 at "Science Signaling"
DOI: 10.1126/scisignal.aan2694
Abstract: Microtubules position ion channels close to each other to ensure autoregulation of vascular tone in cerebral arteries. Supporting ion channel coupling in smooth muscle Cerebral resistance arteries must autoregulate their vascular tone to maintain a… read more here.
Keywords: muscle; sarcoplasmic reticulum; smooth muscle; peripheral coupling ... See more keywords
Puerarin Enhances Ca2+ Reuptake and Ca2+ Content of Sarcoplasmic Reticulum in Murine Embryonic Stem Cell-Derived Cardiomyocytes via Upregulation of SERCA2a
Sign Up to like & getrecommendations! Published in 2017 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000485450
Abstract: Background/Aims: The embryonic stem cell-derived cardiomyocytes (ES-CMs) serve as potential sources for cardiac regenerative therapy. However, the immature sarcoplasmic reticulum (SR) function of ES-CMs prevents its application. In this report, we examined the effect of… read more here.
Keywords: ca2 content; puerarin; sarcoplasmic reticulum; cell ... See more keywords
Abstract 15747: The Sarcoplasmic Reticulum Calcium ATPase Pump Modulates Whole-body Glucose Homeostasis Through a Protein Disulfide Isomerase-dependent Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circ.142.suppl_3.15747
Abstract: Introduction: The heart is a very active metabolic organ which exerts endocrine effects by secreting cardiokines. However, its role in regulating whole-body metabolism has received scarce attention... read more here.
Keywords: body; sarcoplasmic reticulum; abstract 15747; reticulum calcium ... See more keywords
Impaired Dynamic Sarcoplasmic Reticulum Ca Buffering in Autosomal Dominant CPVT2
Sign Up to like & getrecommendations! Published in 2022 at "Circulation Research"
DOI: 10.1161/circresaha.121.320661
Abstract: Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially lethal cardiac arrhythmia syndrome triggered by catecholamines released during exercise, stress, or sudden emotion. Variants in the calsequestrin-2 gene (CASQ2), encoding the major calcium (Ca) binding… read more here.
Keywords: dominant cpvt2; sarcoplasmic reticulum; cpvt2; autosomal dominant ... See more keywords
A computational model of spatio-temporal cardiac intracellular calcium handling with realistic structure and spatial flux distribution from sarcoplasmic reticulum and t-tubule reconstructions
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1005714
Abstract: Intracellular calcium cycling is a vital component of cardiac excitation-contraction coupling. The key structures responsible for controlling calcium dynamics are the cell membrane (comprising the surface sarcolemma and transverse-tubules), the intracellular calcium store (the sarcoplasmic… read more here.
Keywords: intracellular calcium; model; sarcoplasmic reticulum; structure ... See more keywords