Sarecycline: First Global Approval
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DOI: 10.1007/s40265-019-1053-4
Abstract: Sarecycline (Seysara™) is an oral, once-daily, tetracycline-class drug for which a tablet formulation is approved in the USA for the treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris in patients aged ≥ 9 years. The… read more here.
Keywords: dermatology; sarecycline; global approval; sarecycline first ... See more keywords
Reduced blood-brain barrier penetration of acne vulgaris antibiotic sarecycline compared to minocycline corresponds with lower lipophilicity
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DOI: 10.3389/fmed.2022.1033980
Abstract: Background Vestibular side effects such as dizziness and vertigo can be a limitation for some antibiotics commonly used to treat acne, rosacea, and other dermatology indications. Objective Unlike minocycline, which is a second-generation tetracycline, sarecycline,… read more here.
Keywords: acne vulgaris; blood brain; sarecycline; brain ... See more keywords
Profiling the Effects of Systemic Antibiotics for Acne, Including the Narrow-Spectrum Antibiotic Sarecycline, on the Human Gut Microbiota
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DOI: 10.3389/fmicb.2022.901911
Abstract: Treatment for moderate-to-severe acne vulgaris relies on prolonged use of oral tetracycline-class antibiotics; however, these broad-spectrum antibiotics are often associated with off-target effects and negative gastrointestinal sequelae. Sarecycline is a narrow-spectrum antibiotic treatment option. Here,… read more here.
Keywords: spectrum antibiotic; microbiota; gut microbiota; narrow spectrum ... See more keywords
Antibacterial Mechanisms and Efficacy of Sarecycline in Animal Models of Infection and Inflammation
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DOI: 10.3390/antibiotics10040439
Abstract: Prolonged broad-spectrum antibiotic use is more likely to induce bacterial resistance and dysbiosis of skin and gut microflora. First and second-generation tetracycline-class antibiotics have similar broad-spectrum antibacterial activity. Targeted tetracycline-class antibiotics are needed to limit… read more here.
Keywords: sarecycline; antibacterial mechanisms; models infection; infection inflammation ... See more keywords
Sarecycline Demonstrated Reduced Activity Compared to Minocycline against Microbial Species Representing Human Gastrointestinal Microbiota
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DOI: 10.3390/antibiotics11030324
Abstract: Prolonged use of broad-spectrum tetracycline antibiotics such as minocycline and doxycycline may significantly alter the gut and skin microbiome leading to dysbiosis. Sarecycline, a narrow-spectrum tetracycline-class antibiotic used for acne treatment, is hypothesized to have… read more here.
Keywords: microbiota; sarecycline demonstrated; sarecycline; demonstrated reduced ... See more keywords