Lessons learned from the preclinical discovery and development of sarilumab for the treatment of rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2022.2093852
Abstract: ABSTRACT Introduction Rheumatoid arthritis (RA) pathogenesis is driven by a complex network of proinflammatory cytokines, among which interleukin-6 (IL-6) plays a key role in inducing and perpetuating chronic inflammation. Targeting the IL-6 pathway has shown… read more here.
Keywords: sarilumab treatment; treatment; sarilumab; rheumatoid arthritis ... See more keywords
A review of sarilumab for the treatment of rheumatoid arthritis.
Sign Up to like & getrecommendations! Published in 2018 at "Immunotherapy"
DOI: 10.2217/imt-2017-0075
Abstract: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease predominantly affecting the peripheral diarthrodial joints. Sarilumab is a human monoclonal antibody against the IL-6 receptor-α. In Phase II and III clinical trials, sarilumab in the… read more here.
Keywords: sarilumab treatment; review sarilumab; rheumatoid arthritis; inadequate response ... See more keywords