Effects of novel brain‐penetrating oxime acetylcholinesterase reactivators on sarin surrogate‐induced changes in rat brain gene expression
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22755
Abstract: Past assassinations and terrorist attacks demonstrate the need for a more effective antidote against nerve agents and other organophosphates (OP) that cause brain damage through inhibition of acetylcholinesterase (AChE). Our lab has invented a platform… read more here.
Keywords: sarin surrogate; acetylcholinesterase; gene expression; expression ... See more keywords
Persistent brainwave disruption and cognitive impairment induced by acute sarin surrogate sub-lethal dose exposure.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology"
DOI: 10.1016/j.tox.2021.152787
Abstract: Warfare neurotoxicants such as sarin, soman or VX, are organophosphorus compounds which irreversibly inhibit cholinesterase. High-dose exposure with nerve agents (NA) is known to produce seizure activity and related brain damage, while less is known… read more here.
Keywords: sarin surrogate; sub lethal; exposure; lethal dose ... See more keywords