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Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7594
Abstract: Chronic acrylamide (ACR) intoxication causes typical pathology of axon degeneration. Moreover, sterile‐α and toll/interleukin 1 receptor motif‐containing protein 1 (SARM1), the central executioner of the programmed axonal destruction process under various insults, is up‐regulated in…
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Keywords:
dependent axon;
sarm1 dependent;
axon degeneration;
berberine chloride ... See more keywords
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Published in 2020 at "Molecular neurobiology"
DOI: 10.1007/s12035-020-02132-9
Abstract: Sterile alpha and Toll/interleukin-1 receptor motif-containing 1 (SARM1) is a pro-degenerative molecule in Wallerian degeneration, which is mainly expressed in brain/neurons and colocalized with mitochondria and microtubules. The aim of this study was to determine…
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Keywords:
sarm1;
reperfusion;
injury;
phosphorylation s548 ... See more keywords
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Published in 2021 at "Protein & Cell"
DOI: 10.1007/s13238-021-00835-w
Abstract: Axonal degeneration is one of the key features of neurodegenerative disorders. In the canonical view, axonal degeneration destructs neural connections and promotes detrimental disease defects. Here, we assessed the enteric nervous system (ENS) of the…
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Keywords:
sarm1;
inflammation;
colon;
neurodegeneration ... See more keywords
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Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109872
Abstract: SARM1 is an inducible TIR-domain NAD+ hydrolase that mediates pathological axon degeneration. SARM1 is activated by an increased ratio of NMN to NAD+, which competes for binding to an allosteric activating site. When NMN binds,…
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Keywords:
sarm1;
subvert allosteric;
allosteric activation;
neurotoxins subvert ... See more keywords
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Published in 2020 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2020.113252
Abstract: SARM1 is the central executioner of pathological axon degeneration, promoting axonal demise in response to axotomy, traumatic brain injury, and neurotoxic chemotherapeutics that induce peripheral neuropathy. SARM1 is an injury-activated NAD+ cleavage enzyme, and this…
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Keywords:
sarm1 activity;
sarm1;
cadpr;
biomarker ... See more keywords
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Published in 2021 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2021.113842
Abstract: SARM1 is an inducible NAD+ hydrolase that is the central executioner of pathological axon loss. Recently, we elucidated the molecular mechanism of SARM1 activation, demonstrating that SARM1 is a metabolic sensor regulated by the levels…
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Keywords:
nad hydrolase;
sarm1;
nicotinic acid;
allosteric site ... See more keywords
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Published in 2022 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-021-00511-x
Abstract: Background In response to injury, neurons activate a program of organized axon self-destruction initiated by the NAD + hydrolase, SARM1. In healthy neurons SARM1 is autoinhibited, but single amino acid changes can abolish autoinhibition leading…
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Keywords:
sarm1;
sarm1 variants;
als patients;
sarm1 alleles ... See more keywords
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Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1010246
Abstract: SARM1 is the founding member of the TIR-domain family of NAD+ hydrolases and the central executioner of pathological axon degeneration. SARM1-dependent degeneration requires NAD+ hydrolysis. Prior to the discovery that SARM1 is an enzyme, SARM1…
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Keywords:
nadase activity;
developmental signaling;
activity;
sarm1 ... See more keywords
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1
Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0267720
Abstract: Prion diseases are a group of fatal, transmissible neurodegenerative diseases of mammals. In the brain, axonal loss and neuronal death are prominent in prion infection, but the mechanisms remain poorly understood. Sterile alpha and heat/Armadillo…
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Keywords:
prion;
molecule;
sarm1;
mitochondrial respiration ... See more keywords
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Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.852114
Abstract: SARM1 (sterile alpha and armadillo motif-containing protein) is a highly conserved Toll/IL-1 Receptor (TIR) adaptor with important roles in mediating immune responses. Studies in the brain have shown that SARM1 plays a role in induction…
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Keywords:
degeneration;
retinal degeneration;
oxidative stress;
sarm1 ... See more keywords
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Published in 2021 at "eLife"
DOI: 10.7554/elife.70905
Abstract: SARM1, a protein with critical NADase activity, is a central executioner in a conserved programme of axon degeneration. We report seven rare missense or in-frame microdeletion human SARM1 variant alleles in patients with amyotrophic lateral…
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Keywords:
als motor;
nadase;
activity;
sarm1 ... See more keywords