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   Articles with "sarm1" as a keyword



The therapeutic potential of berberine chloride against SARM1‐dependent axon degeneration in acrylamide‐induced neuropathy

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recommendations! Published in 2022 at "Phytotherapy Research"

DOI: 10.1002/ptr.7594

Abstract: Chronic acrylamide (ACR) intoxication causes typical pathology of axon degeneration. Moreover, sterile‐α and toll/interleukin 1 receptor motif‐containing protein 1 (SARM1), the central executioner of the programmed axonal destruction process under various insults, is up‐regulated in… read more here.

Keywords: dependent axon; sarm1 dependent; axon degeneration; berberine chloride ... See more keywords

Phosphorylation at S548 as a Functional Switch of Sterile Alpha and TIR Motif-Containing 1 in Cerebral Ischemia/Reperfusion Injury in Rats.

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recommendations! Published in 2020 at "Molecular neurobiology"

DOI: 10.1007/s12035-020-02132-9

Abstract: Sterile alpha and Toll/interleukin-1 receptor motif-containing 1 (SARM1) is a pro-degenerative molecule in Wallerian degeneration, which is mainly expressed in brain/neurons and colocalized with mitochondria and microtubules. The aim of this study was to determine… read more here.

Keywords: sarm1; reperfusion; injury; phosphorylation s548 ... See more keywords

Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon

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recommendations! Published in 2021 at "Protein & Cell"

DOI: 10.1007/s13238-021-00835-w

Abstract: Axonal degeneration is one of the key features of neurodegenerative disorders. In the canonical view, axonal degeneration destructs neural connections and promotes detrimental disease defects. Here, we assessed the enteric nervous system (ENS) of the… read more here.

Keywords: sarm1; inflammation; colon; neurodegeneration ... See more keywords

Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss.

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recommendations! Published in 2021 at "Cell reports"

DOI: 10.1016/j.celrep.2021.109872

Abstract: SARM1 is an inducible TIR-domain NAD+ hydrolase that mediates pathological axon degeneration. SARM1 is activated by an increased ratio of NMN to NAD+, which competes for binding to an allosteric activating site. When NMN binds,… read more here.

Keywords: sarm1; subvert allosteric; allosteric activation; neurotoxins subvert ... See more keywords
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cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons

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recommendations! Published in 2020 at "Experimental Neurology"

DOI: 10.1016/j.expneurol.2020.113252

Abstract: SARM1 is the central executioner of pathological axon degeneration, promoting axonal demise in response to axotomy, traumatic brain injury, and neurotoxic chemotherapeutics that induce peripheral neuropathy. SARM1 is an injury-activated NAD+ cleavage enzyme, and this… read more here.

Keywords: sarm1 activity; sarm1; cadpr; biomarker ... See more keywords
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Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection

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recommendations! Published in 2021 at "Experimental Neurology"

DOI: 10.1016/j.expneurol.2021.113842

Abstract: SARM1 is an inducible NAD+ hydrolase that is the central executioner of pathological axon loss. Recently, we elucidated the molecular mechanism of SARM1 activation, demonstrating that SARM1 is a metabolic sensor regulated by the levels… read more here.

Keywords: nad hydrolase; sarm1; nicotinic acid; allosteric site ... See more keywords

Optimization of Brain Penetrant SARM1 Orthosteric Inhibitors and Discovery of Their Paradoxical Subinhibitory Activation.

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recommendations! Published in 2025 at "ACS medicinal chemistry letters"

DOI: 10.1021/acsmedchemlett.5c00189

Abstract: SARM1 (sterile alpha and Toll/interleukin-1 receptor motif-containing 1) has recently emerged as a promising therapeutic target for several neurodegenerative diseases. Herein, we detail our optimization of SARM1 orthosteric base exchange inhibitors. Early chemical matter was… read more here.

Keywords: sarm1; optimization brain; brain; penetrant sarm1 ... See more keywords

Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients

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recommendations! Published in 2022 at "Molecular Neurodegeneration"

DOI: 10.1186/s13024-021-00511-x

Abstract: Background In response to injury, neurons activate a program of organized axon self-destruction initiated by the NAD + hydrolase, SARM1. In healthy neurons SARM1 is autoinhibited, but single amino acid changes can abolish autoinhibition leading… read more here.

Keywords: sarm1; sarm1 variants; als patients; sarm1 alleles ... See more keywords

Loss of Sarm1 reduces retinal ganglion cell loss in chronic glaucoma

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recommendations! Published in 2024 at "Acta Neuropathologica Communications"

DOI: 10.1186/s40478-024-01736-9

Abstract: Glaucoma is one of the leading causes of irreversible blindness worldwide and vision loss in the disease results from the deterioration of retinal ganglion cells (RGC) and their axons. Metabolic dysfunction of RGC plays a… read more here.

Keywords: mice; sarm1; loss; retinal ganglion ... See more keywords

Distinct developmental and degenerative functions of SARM1 require NAD+ hydrolase activity

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recommendations! Published in 2022 at "PLoS Genetics"

DOI: 10.1371/journal.pgen.1010246

Abstract: SARM1 is the founding member of the TIR-domain family of NAD+ hydrolases and the central executioner of pathological axon degeneration. SARM1-dependent degeneration requires NAD+ hydrolysis. Prior to the discovery that SARM1 is an enzyme, SARM1… read more here.

Keywords: nadase activity; developmental signaling; activity; sarm1 ... See more keywords

Lack of the immune adaptor molecule SARM1 accelerates disease in prion infected mice and is associated with increased mitochondrial respiration and decreased expression of NRF2

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recommendations! Published in 2022 at "PLoS ONE"

DOI: 10.1371/journal.pone.0267720

Abstract: Prion diseases are a group of fatal, transmissible neurodegenerative diseases of mammals. In the brain, axonal loss and neuronal death are prominent in prion infection, but the mechanisms remain poorly understood. Sterile alpha and heat/Armadillo… read more here.

Keywords: prion; molecule; sarm1; mitochondrial respiration ... See more keywords