cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons
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DOI: 10.1016/j.expneurol.2020.113252
Abstract: SARM1 is the central executioner of pathological axon degeneration, promoting axonal demise in response to axotomy, traumatic brain injury, and neurotoxic chemotherapeutics that induce peripheral neuropathy. SARM1 is an injury-activated NAD+ cleavage enzyme, and this… read more here.
Keywords: sarm1 activity; sarm1; cadpr; biomarker ... See more keywords