Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-021-00511-x
Abstract: Background In response to injury, neurons activate a program of organized axon self-destruction initiated by the NAD + hydrolase, SARM1. In healthy neurons SARM1 is autoinhibited, but single amino acid changes can abolish autoinhibition leading… read more here.
Keywords: sarm1; sarm1 variants; als patients; sarm1 alleles ... See more keywords