The therapeutic potential of berberine chloride against SARM1‐dependent axon degeneration in acrylamide‐induced neuropathy
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7594
Abstract: Chronic acrylamide (ACR) intoxication causes typical pathology of axon degeneration. Moreover, sterile‐α and toll/interleukin 1 receptor motif‐containing protein 1 (SARM1), the central executioner of the programmed axonal destruction process under various insults, is up‐regulated in… read more here.
Keywords: dependent axon; sarm1 dependent; axon degeneration; berberine chloride ... See more keywords
DLK Activation Synergizes with Mitochondrial Dysfunction to Downregulate Axon Survival Factors and Promote SARM1-Dependent Axon Degeneration
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DOI: 10.1007/s12035-019-01796-2
Abstract: Axon degeneration is a prominent component of many neurological disorders. Identifying cellular pathways that contribute to axon vulnerability may identify new therapeutic strategies for maintenance of neural circuits. Dual leucine zipper kinase (DLK) is an… read more here.
Keywords: dlk; degeneration; axon survival; sarm1 dependent ... See more keywords
Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109872
Abstract: SARM1 is an inducible TIR-domain NAD+ hydrolase that mediates pathological axon degeneration. SARM1 is activated by an increased ratio of NMN to NAD+, which competes for binding to an allosteric activating site. When NMN binds,… read more here.
Keywords: sarm1; subvert allosteric; allosteric activation; neurotoxins subvert ... See more keywords