Sarm1 haploinsufficiency or low expression levels after antisense oligonucleotides delay programmed axon degeneration
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DOI: 10.1016/j.celrep.2021.110108
Abstract: Summary Activation of the pro-degenerative protein SARM1 after diverse physical and disease-relevant injuries causes programmed axon degeneration. Original studies indicate that substantially decreased SARM1 levels are required for neuroprotection. However, we demonstrate, in Sarm1 haploinsufficient… read more here.
Keywords: programmed axon; degeneration; axon degeneration; sarm1 levels ... See more keywords