Relationship between circulating senescence-associated secretory phenotype levels and severity of type 2 diabetes-associated periodontitis: A cross-sectional study.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of periodontology"
DOI: 10.1002/jper.22-0445
Abstract: BACKGROUND Senescence-associated secretory phenotype (SASP) has recently been found to drive comorbid diabetes and periodontitis by inducing a chronic, low-degree inflammatory state. Here, we sought to explore the relationship between circulating SASP and severity of… read more here.
Keywords: sasp; group; periodontitis; severity ... See more keywords
Attenuation of inflammation and cartilage degradation by sulfasalazine-containing hyaluronic acid on osteoarthritis rat model.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.03.059
Abstract: The aim of this study was to investigate the effects of a sulfasalazine-containing hyaluronic acid (SASP/HA) systems on in vitro anti-inflammation and the alleviation of cartilage degradation in both lipopolysaccharide (LPS)-stimulated synoviocytes and a rat… read more here.
Keywords: sasp; sulfasalazine containing; inflammation; cartilage degradation ... See more keywords
SASP regulation by noncoding RNA
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2017.05.004
Abstract: Noncoding RNAs (ncRNAs), including micro (mi)RNAs, long noncoding (lnc)RNAs, and circular (circ)RNAs, control specific gene expression programs by regulating transcriptional, post-transcriptional, and post-translational processes. Through their broad influence on protein expression and function, ncRNAs have… read more here.
Keywords: noncoding rna; sasp; senescence; regulation noncoding ... See more keywords
AISA can control the inflammatory facet of SASP
Sign Up to like & getrecommendations! Published in 2020 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2019.111206
Abstract: Senescent cells have been suspected, because of their secretory phenotype (SASP or senescence associated secretory profile), to contribute to the extension of the chronic inflammatory condition leading to unhealthy aging processes. AISA (Anti-Inflammatory Senescence Actives).… read more here.
Keywords: anti inflammatory; sasp; control inflammatory; inflammatory ... See more keywords
Cellular Senescence: The Sought or the Unwanted?
Sign Up to like & getrecommendations! Published in 2018 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2018.08.002
Abstract: Cellular senescence is a process that results in irreversible cell-cycle arrest, and is thought to be an autonomous tumor-suppressor mechanism. During senescence, cells develop distinctive metabolic and signaling features, together referred to as the senescence-associated… read more here.
Keywords: medicine; sasp; senescence; sought unwanted ... See more keywords
The role of lamin B receptor in the regulation of senescence-associated secretory phenotype (SASP).
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.111927
Abstract: Cellular senescence is a phenomenon of irreversible growth arrest of mammalian somatic cells. Senescent cells increase the production of secretory proteins such as inflammatory cytokines, a phenomenon termed senescence-associated secretory phenotype (SASP). SASP is known… read more here.
Keywords: lbr; senescent cells; sasp; senescence ... See more keywords
Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01992-5
Abstract: Senescent cells may promote tumour progression through the activation of a senescence-associated secretory phenotype (SASP), whether these cells are capable of initiating tumourigenesis in vivo is not known. Expression of oncogenic β-catenin in Sox2+ young… read more here.
Keywords: stem cell; sasp; senescence; induction ... See more keywords
NOTCH and the 2 SASPs of senescence
Sign Up to like & getrecommendations! Published in 2017 at "Cell Cycle"
DOI: 10.1080/15384101.2016.1248730
Abstract: The previous view that cellular senescence represented a stressresponsive tumor suppressor mechanism has been significantly revised recently with recognition of the profound non-autonomous functionality of senescent cells. Senescent cells interact with surrounding normal and transformed… read more here.
Keywords: senescent cells; sasp; senescence; notch ... See more keywords
Link between senescence and cell fate: Senescence-associated secretory phenotype (SASP) and its effects on stem cell fate transition.
Sign Up to like & getrecommendations! Published in 2022 at "Rejuvenation research"
DOI: 10.1089/rej.2022.0021
Abstract: Senescence is a form of durable cell cycle arrest elicited in response to a wide range of stimuli. Senescent cells remain metabolically active and secrete a variety of factors collectively termed senescence-associated secretory phenotype (SASP).… read more here.
Keywords: cell fate; cell; sasp; senescence ... See more keywords
Arabidopsis subtilase SASP is involved in the regulation of ABA signaling and drought tolerance by interacting with OPEN STOMATA 1
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Experimental Botany"
DOI: 10.1093/jxb/ery205
Abstract: Arabidopsis Senescence-Associated Subtilisin Protease (SASP) has previously been reported to participate in leaf senescence and in the development of inflorescences and siliques. Here, we describe a new role of SASP in the regulation of abscisic… read more here.
Keywords: open stomata; sasp; drought tolerance; aba signaling ... See more keywords
Melatonin regulates PARP1 to control the senescence‐associated secretory phenotype (SASP) in human fetal lung fibroblast cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pineal Research"
DOI: 10.1111/jpi.12405
Abstract: Cellular senescence is an important tumor‐suppressive mechanism. However, acquisition of a senescence‐associated secretory phenotype (SASP) in senescent cells has deleterious effects on the tissue microenvironment and, paradoxically, promotes tumor progression. In a drug screen, we… read more here.
Keywords: secretory phenotype; senescence associated; sasp; associated secretory ... See more keywords