Estrogen regulates stemness and senescence of bone marrow stromal cells to prevent osteoporosis via ERβ‐SATB2 pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26233
Abstract: Decline of pluripotency in bone marrow stromal cells (BMSCs) associated with estrogen deficiency leads to a bone formation defect in osteoporosis. Special AT‐rich sequence binding protein 2 (SATB2) is crucial for maintaining stemness and osteogenic… read more here.
Keywords: satb2; estrogen; senescence; bone ... See more keywords
Satb2 Ablation Impairs Hippocampus-Based Long-Term Spatial Memory and Short-Term Working Memory and Immediate Early Genes (IEGs)-Mediated Hippocampal Synaptic Plasticity
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0531-5
Abstract: Special AT-rich sequence-binding protein 2 (Satb2) is a protein binding to the matrix attachment regions of DNA and important for gene regulation. Patients with SATB2 mutation usually suffer moderate to severe mental retardation. However, the… read more here.
Keywords: term; spatial memory; working memory; mice ... See more keywords
Hepatocellular Carcinomas can be SATB2 positive: An Important Diagnostic Pitfall.
Sign Up to like & getrecommendations! Published in 2020 at "Human pathology"
DOI: 10.1016/j.humpath.2020.09.001
Abstract: SATB2 is a sensitive and specific marker for tumors originating with the colon and appendix. It is now commonly used in surgical pathology, while working up carcinomas of unknown primary. We had anecdotally encountered occasional… read more here.
Keywords: satb2 positive; pathology; hepatocellular carcinomas; satb2 expression ... See more keywords
The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-018-07846-y
Abstract: Epigenetically regulated transcriptional plasticity has been proposed as a mechanism of differentiation arrest and resistance to therapy. BCR-ABL leukemias result from leukemic stem cell/progenitor transformation and represent an opportunity to identify epigenetic progress contributing to… read more here.
Keywords: differentiation arrest; kinase; transformation; differentiation ... See more keywords
SATB2 is a novel biomarker and therapeutic target for cancer
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15755
Abstract: Several studies have confirmed the involvement of cancer stem cells (CSC) in tumour progression, metastasis, drug resistance and cancer relapse. SATB2 (special AT‐rich binding protein‐2) acts as a transcriptional co‐factor and modulates chromatin architecture to… read more here.
Keywords: target cancer; expression; therapeutic target; cancer ... See more keywords
Effects of miR-103 by negatively regulating SATB2 on proliferation and osteogenic differentiation of human bone marrow mesenchymal stem cells
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0232695
Abstract: Background The proliferation and osteogenic differentiation of human bone marrow mesenchymal stem cells (HBMScs) are modulated by a variety of microRNAs (miRNAs). SATB homeobox 2 (SATB2) is a critical transcription factor that contributes to maintain… read more here.
Keywords: proliferation osteogenic; mir 103; osteogenic differentiation; satb2 ... See more keywords
SATB2 drives glioblastoma growth by recruiting CBP to promote FOXM1 expression in glioma stem cells
Sign Up to like & getrecommendations! Published in 2020 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202012291
Abstract: Nuclear matrix‐associated proteins (NMPs) play critical roles in regulating chromatin organization and gene transcription by binding to the matrix attachment regions (MARs) of DNA. However, the functional significance of NMPs in glioblastoma (GBM) progression remains… read more here.
Keywords: proliferation; expression; promote; cbp promote ... See more keywords
Diagnostic accuracy of SATB2 in identifying primary and metastatic colorectal carcinoma: a comparative immunohistochemical study
Sign Up to like & getrecommendations! Published in 2022 at "ecancermedicalscience"
DOI: 10.3332/ecancer.2022.1491
Abstract: Special AT-rich sequence-binding protein 2 (SATB2) is a new marker that could identify the colonic origin, but whether its expression is preserved in metastatic colorectal carcinomas (CRCs) remains unclear. This study was designed to investigate… read more here.
Keywords: metastatic colorectal; cdx2; expression; crc ... See more keywords
SATB2 and MDM2 Immunoexpression and Diagnostic Role in Primary Osteosarcomas of the Jaw.
Sign Up to like & getrecommendations! Published in 2021 at "Dentistry journal"
DOI: 10.3390/dj10010004
Abstract: Primary osteosarcomas of the jaw (OSJ) are rare, accounting for 6% of all osteosarcomas. This study aims to determine the value of SATB2 and MDM2 immunohistochemistry (IHC) in differentiating OSJ from other jawbone mimickers, such… read more here.
Keywords: marker; satb2; medicine; ewing sarcoma ... See more keywords
RUNX2/miR‑31/SATB2 pathway in nickel‑induced BEAS‑2B cell transformation.
Sign Up to like & getrecommendations! Published in 2021 at "Oncology reports"
DOI: 10.3892/or.2021.8105
Abstract: Nickel (Ni) compounds are classified as Group 1 carcinogens by the International Agency for Research on Cancer (IARC) and are known to be carcinogenic to the lungs. In our previous study, special AT‑rich sequence‑binding protein 2… read more here.
Keywords: mir; transformation; expression; cell transformation ... See more keywords