Dehydrogenative reagent-free annulation of alkenes with diols for the synthesis of saturated O-heterocycles
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06020-8
Abstract: Dehydrogenative annulation reactions are among the most straightforward and efficient approach for the preparation of cyclic structures. However, the applications of this strategy for the synthesis of saturated heterocycles have been rare. In addition, reported… read more here.
Keywords: dehydrogenative annulation; annulation; synthesis saturated; alkenes diols ... See more keywords
Diverse saturated heterocycles from a hydroacylation/conjugate addition cascade
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d1sc06900d
Abstract: Rhodium-catalyzed hydroacylation using alkynes substituted with pendant nucleophiles, delivers linear α,β-unsaturated enone intermediates with excellent regioselectivity. These adducts are used to construct a broad range of diversely substituted, saturated O-, N- and S-heterocycles in a… read more here.
Keywords: hydroacylation conjugate; conjugate addition; saturated heterocycles; heterocycles hydroacylation ... See more keywords