t-BuOK-Induced, NH3·MeOH-Promoted Electrochemical C(sp3)-H Amination of Saturated Heterocycles with Sulfoximines.
Sign Up to like & getrecommendations! Published in 2025 at "Organic letters"
DOI: 10.1021/acs.orglett.5c02042
Abstract: The t-BuOK-induced electrochemical C(sp3)-H amination of saturated heterocycles with sulfoximines was reported. t-BuOK rather than dangerous peroxides was used as the precursor of the tert-butoxy radical, which was induced by electrochemistry; this process has not… read more here.
Keywords: amination saturated; saturated heterocycles; buok induced; sp3 amination ... See more keywords
Bifunctional Imine Reductase Cascades for the Synthesis of Saturated N-Heterocycles
Sign Up to like & getrecommendations! Published in 2024 at "ACS Catalysis"
DOI: 10.1021/acscatal.4c03832
Abstract: Saturated N-heterocycles constitute a vital scaffold for pharmaceutical chemistry but are challenging to access synthetically, particularly asymmetrically. Here, we demonstrate how imine reductases can achieve annulation through tandem inter- and intramolecular reductive amination processes. Imine… read more here.
Keywords: bifunctional imine; imine reductase; saturated heterocycles; reductase cascades ... See more keywords
Dehydrogenative reagent-free annulation of alkenes with diols for the synthesis of saturated O-heterocycles
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06020-8
Abstract: Dehydrogenative annulation reactions are among the most straightforward and efficient approach for the preparation of cyclic structures. However, the applications of this strategy for the synthesis of saturated heterocycles have been rare. In addition, reported… read more here.
Keywords: dehydrogenative annulation; annulation; synthesis saturated; alkenes diols ... See more keywords
Diverse saturated heterocycles from a hydroacylation/conjugate addition cascade
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d1sc06900d
Abstract: Rhodium-catalyzed hydroacylation using alkynes substituted with pendant nucleophiles, delivers linear α,β-unsaturated enone intermediates with excellent regioselectivity. These adducts are used to construct a broad range of diversely substituted, saturated O-, N- and S-heterocycles in a… read more here.
Keywords: hydroacylation conjugate; conjugate addition; saturated heterocycles; heterocycles hydroacylation ... See more keywords
Electrochemically chalcogenative annulation enabled construction of functionalized saturated N-heterocycles.
Sign Up to like & getrecommendations! Published in 2024 at "Chemical communications"
DOI: 10.1039/d4cc03432e
Abstract: An efficient chalcogenative annulation strategy for constructing functionalized saturated N-heterocycles from unactivated alkenes with dichalcogenides under electrochemical conditions has been presented. This protocol is applicable to mono-, di- or tri-substituted alkenes, providing a straightforward pathway… read more here.
Keywords: saturated heterocycles; functionalized saturated; electrochemically chalcogenative; annulation enabled ... See more keywords
Recent advances in transition-metal-free deconstructive functionalization of saturated N-, O-, P-, and S-heterocycles.
Sign Up to like & getrecommendations! Published in 2025 at "Chemical communications"
DOI: 10.1039/d5cc05893g
Abstract: Saturated heterocycles containing oxygen, nitrogen, sulfur, and phosphorus are prevalent structural motifs in natural products, pharmaceuticals, and functional materials. Although significant progress has been made in the direct functionalization of their peripheral C-H bonds, the… read more here.
Keywords: transition metal; saturated heterocycles; advances transition; functionalization ... See more keywords