Physiologically based pharmacokinetic modeling characterizes the drug-drug interaction between saxagliptin and rifampicin in patients with renal impairment.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of clinical pharmacology"
DOI: 10.1002/jcph.2223
Abstract: The aim of the present study is to develop physiologically based pharmacokinetic (PBPK) models for saxagliptin and its active metabolite, 5-hydroxy saxagliptin, and to predict the effect of co-administration of rifampicin, a strong inducer of… read more here.
Keywords: hydroxy saxagliptin; renal impairment; rifampicin; drug ... See more keywords
The DPP‐4 inhibitor saxagliptin ameliorates ox‐LDL‐induced endothelial dysfunction by regulating AP‐1 and NF‐&kgr;B
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2019.01.008
Abstract: Abstract Diabetes‐associated cardiovascular complications are the leading cause of death for diabetic patients. Dipeptidyl peptidase 4 (DPP‐4) inhibitor agents, known as gliptins, are a class of potent anti‐glycemic agents developed to treat diabetes. Recently, gliptins… read more here.
Keywords: dpp inhibitor; adhesion; ldl induced; saxagliptin ... See more keywords
Activation of AMPK/mTOR-driven autophagy and inhibition of NLRP3 inflammasome by saxagliptin ameliorate ethanol-induced gastric mucosal damage.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119743
Abstract: AIMS Saxagliptin, a selective/potent dipeptidyl peptidase-4 inhibitor, has revealed remarkable anti-inflammatory features in murine models of nephrotoxicity, hepatic injury, and neuroinflammation. However, its potential effect on ethanol-induced gastric mucosal injury has not been examined. Hence,… read more here.
Keywords: gastric mucosal; ampk mtor; mtor; ethanol induced ... See more keywords
Efficacy and safety of saxagliptin in combination with insulin in Japanese patients with type 2 diabetes mellitus: a 16-week double-blind randomized controlled trial with a 36-week open-label extension
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2017.1379990
Abstract: ABSTRACT Background: We examined the efficacy and safety of saxagliptin as an add-on to insulin in Japanese patients with type 2 diabetes mellitus. Research design and methods: We randomized 240 patients with type 2 diabetes… read more here.
Keywords: patients type; week; efficacy safety; safety saxagliptin ... See more keywords
Simultaneous Estimation of Saxagliptin and Dapagliflozin in Human Plasma by Validated High Performance Liquid Chromatography - Ultraviolet Method
Sign Up to like & getrecommendations! Published in 2019 at "Turkish Journal of Pharmaceutical Sciences"
DOI: 10.4274/tjps.galenos.2018.46547
Abstract: Objectives: The fixed dose combination of saxagliptin and dapagliflozin is a recently approved antidiabetic medication. It is marketed under the brand name Qtern. The aim of this study was to develop a simple, rapid, sensitive,… read more here.
Keywords: human plasma; saxagliptin dapagliflozin; method; dapagliflozin human ... See more keywords