Heterologous Expression of an Unusual Ketosynthase, SxtA, Leads to Production of Saxitoxin Intermediates in Escherichia coli
Sign Up to like & getrecommendations! Published in 2020 at "ChemBioChem"
DOI: 10.1002/cbic.202000675
Abstract: Paralytic shellfish toxins (PSTs) are neurotoxic alkaloids produced by freshwater cyanobacteria and marine dinoflagellates. Due to their antagonism of voltage‐gated sodium channels in excitable cells, certain analogues are of significant pharmacological interest. The biosynthesis of… read more here.
Keywords: unusual ketosynthase; sxta; escherichia coli; expression unusual ... See more keywords
Development of an Electrochemical Biosensor for the Rapid Detection of Saxitoxin Based on Air Stable Lipid Films with Incorporated Anti-STX Using Graphene Electrodes
Sign Up to like & getrecommendations! Published in 2017 at "Electroanalysis"
DOI: 10.1002/elan.201600652
Abstract: A miniaturized potentiometric saxitoxin sensor on graphene nanosheets with incorporated lipid films and Anti-STX, the natural saxitoxin receptor, immobilized on the stabilized lipid films is described in the present paper. An adequate selectivity for detection… read more here.
Keywords: rapid detection; lipid films; detection; anti stx ... See more keywords
Effect of nutrient concentration on growth and saxitoxin production of Raphidiopsis raciborskii (Cyanophyta) interacting with Monoraphidium contortum (Chlorophyceae)
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Applied Phycology"
DOI: 10.1007/s10811-019-01972-w
Abstract: Raphidiopsis raciborskii is the dominant species in several subtropical aquatic ecosystems. This study addressed the influence of nutrient concentration on cyanobacteria growth and saxitoxin synthesis. Therefore, we performed bioassays of interaction between the Chlorophyceae Monoraphidium… read more here.
Keywords: contortum; raciborskii; interaction; raphidiopsis raciborskii ... See more keywords
Chronic exposure to sublethal concentrations of saxitoxin reduces antioxidant activity and immunity in zebrafish but does not affect reproductive parameters.
Sign Up to like & getrecommendations! Published in 2021 at "Aquatic toxicology"
DOI: 10.1016/j.aquatox.2021.106070
Abstract: Saxitoxin produced by dinoflagellates and cyanobacteria can be transferred to humans through intoxicated organisms such as fish, but limited research has addressed the adverse effects of this toxin on aquatic organisms. In this study, we… read more here.
Keywords: affect reproductive; saxitoxin; reproductive parameters; exposure ... See more keywords
Quantification of saxitoxin in human blood by ELISA
Sign Up to like & getrecommendations! Published in 2017 at "Toxicon"
DOI: 10.1016/j.toxicon.2017.05.009
Abstract: Abstract Saxitoxin (STX) is a potent marine toxin that causes paralytic shellfish poisoning (PSP) which can result in significant morbidity and mortality in humans. Low lethal doses, rapid onset of PSP symptoms, and brief STX… read more here.
Keywords: psp; human blood; saxitoxin human; blood ... See more keywords
Molecular and morphological survey of saxitoxin‐producing cyanobacterium Dolichospermum circinale (Anabaena circinalis) isolated from geographically distinct regions of Australia
Sign Up to like & getrecommendations! Published in 2017 at "Toxicon"
DOI: 10.1016/j.toxicon.2017.08.006
Abstract: &NA; The cyanobacterium Dolichospermum circinale (formerly Anabaena circinalis) is responsible for neurotoxic saxitoxin‐producing blooms in Australia. Previous studies have reported distinct isolates of toxic D. circinale producing different saxitoxin analogues at varying amounts, but the… read more here.
Keywords: anabaena circinalis; cyanobacterium dolichospermum; presence; toxin ... See more keywords
Uncovering the proteome response of murine neuroblastoma cells against low-dose exposure to saxitoxin
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology Mechanisms and Methods"
DOI: 10.1080/15376516.2017.1411413
Abstract: Abstract The potent neurotoxin saxitoxin produced by both marine and freshwater phytoplankton causes paralytic shellfish poisoning syndrome. The toxicity and mode of action of the acute exposure of high-dose saxitoxin have been intensively studied for… read more here.
Keywords: low dose; exposure; murine neuroblastoma; dose saxitoxin ... See more keywords
Stability of Saxitoxin in 50% Methanol Fecal Extracts and Raw Feces from Bowhead Whales (Balaena mysticetus)
Sign Up to like & getrecommendations! Published in 2022 at "Marine Drugs"
DOI: 10.3390/md20090547
Abstract: In recent decades, harmful algal blooms (HABs) producing paralytic shellfish toxins (including saxitoxin, STX) have become increasingly frequent in the marine waters of Alaska, USA, subjecting Pacific Arctic and subarctic communities and wildlife to increased… read more here.
Keywords: time; fecal extracts; saxitoxin; marine mammal ... See more keywords
Label-Free Detection of Saxitoxin with Field-Effect Device-Based Biosensor
Sign Up to like & getrecommendations! Published in 2022 at "Nanomaterials"
DOI: 10.3390/nano12091505
Abstract: Saxitoxin (STX) is a highly toxic and widely distributed paralytic shellfish toxin (PSP), posing a serious hazard to the environment and human health. Thus, it is highly required to develop new STX detection approaches that… read more here.
Keywords: label free; saxitoxin; microscopy; pamam dendrimer ... See more keywords
A Novel SELEX Based on Immobilizing Libraries Enables Screening of Saxitoxin Aptamers for BLI Aptasensor Applications
Sign Up to like & getrecommendations! Published in 2022 at "Toxins"
DOI: 10.3390/toxins14030228
Abstract: Saxitoxin (STX) is one of the potent marine biotoxins that has high rate of lethality. However, there are no effective treatments at present, and the existing detection methods need to be further explored because of… read more here.
Keywords: aptasensor; saxitoxin; aptamer 45e; based immobilizing ... See more keywords