Distinctive binding properties of the negative allosteric modulator, [3H]SB269,652, at recombinant dopamine D3 receptors
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DOI: 10.1016/j.ejphar.2017.12.002
Abstract: ABSTRACT Recently, employing radioligand displacement and functional coupling studies, we demonstrated that SB269,652 (N‐[(1r,4r)−4‐[2‐(7‐cyano‐1,2,3,4‐tetrahydroisoquinolin‐2‐yl)ethyl]cyclohexyl]−1H‐indole‐2‐carboxamide) interacts in an atypical manner with dopamine D3 receptor displaying a unique profile reminiscent of a negative allosteric ligand. Here, we… read more here.
Keywords: allosteric modulator; negative allosteric; dopamine; sb269 652 ... See more keywords