Selenium‐sensitive miRNA‐181a‐5p targeting SBP2 regulates selenoproteins expression in cartilage
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13858
Abstract: Selenium (Se) deficiency brings about defects in the biosynthesis of several selenoproteins and has been associated with aberrant chondrogenesis. Selenocysteine (Sec) Insertion Sequence (SECIS) and SECIS binding protein 2 (SBP2) interaction is a very critical… read more here.
Keywords: sbp2; selenium sensitive; c28 cells; expression ... See more keywords
The hsa-miR-181a-5p reduces oxidation resistance by controlling SECISBP2 in osteoarthritis
Sign Up to like & getrecommendations! Published in 2018 at "BMC Musculoskeletal Disorders"
DOI: 10.1186/s12891-018-2273-6
Abstract: BackgroundThe phenotypes of osteoarthritis (OA) consist of cartilage extracellular matrix (ECM) metabolism disorder and the breakdown of cartilage homeostasis, which are induced by pro-inflammatory factors and oxidative stress. Selenoproteins regulated by selenocysteine insertion sequence binding… read more here.
Keywords: hsa mir; sbp2; expression; oxidation resistance ... See more keywords
Role Of The Thyroid Gland In Expression Of The Thyroid Phenotype Of Sbp2 Deficient Mice.
Sign Up to like & getrecommendations! Published in 2019 at "Endocrinology"
DOI: 10.1210/endocr/bqz032
Abstract: Selenocysteine insertion sequence binding protein 2, SBP2 (SECISBP2), is required for selenoprotein synthesis. Partial SBP2 deficiency syndrome manifests characteristic thyroid function tests. The Sbp2 deficiency mouse model, Sbp2 iCKO, replicates this thyroid phenotype and was… read more here.
Keywords: sbp2; thyroid gland; thyroid; mice ... See more keywords