Structural modulation of a periplasmic sugar-binding protein probes into its evolutionary ancestry.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of structural biology"
DOI: 10.1016/j.jsb.2018.09.006
Abstract: Substrate-binding proteins (SBPs) are periplasmic proteins consisting of two α/β domains joined by a hinge region with specificity towards cognate ligands. Based on three-dimensional fold, sugar-specific SBPs have been classified into cluster B and cluster… read more here.
Keywords: binding pocket; sbps; binding protein; sugar binding ... See more keywords
The Repertoire of Solute-Binding Proteins of Model Bacteria Reveals Large Differences in Number, Type, and Ligand Range
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DOI: 10.1128/spectrum.02054-22
Abstract: SBPs are essential components for many transporters, but multiple pieces of more recent evidence indicate that the SBP-mediated stimulation of different transmembrane receptors is a general and widespread signal transduction mechanism in bacteria. The double… read more here.
Keywords: sbp; ligand; signal transduction; repertoire ... See more keywords