The unique Akt inhibitor SC66 suppressed AMPK activity and abolished autophagy through the EGFR‐p62 pathway
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DOI: 10.1002/cbin.11732
Abstract: Akt is usually considered to be a negative regulator of both autophagy and adenosine 5′‐monophosphate (AMP)‐activated protein kinase (AMPK) signaling. In the present study, we found that SC66, a pyridine‐based allosteric Akt inhibitor, suppressed basal… read more here.
Keywords: p62; akt inhibitor; sc66; akt ... See more keywords
Targeting Akt by SC66 triggers GSK-3β mediated apoptosis in colon cancer therapy
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DOI: 10.1186/s12935-019-0837-7
Abstract: BackgroundColon cancer is one of the three common malignant tumors, with lower 5 years survival rate. Akt is an important therapeutic target, while SC66 is a novel allosteric AKT inhibitor, which enhances the therapeutic effect in… read more here.
Keywords: apoptosis; colon cancer; cancer; gsk ... See more keywords