Lack of hydroxyurea‐associated mutagenesis in pediatric sickle cell disease patients
Sign Up to like & getrecommendations! Published in 2023 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22536
Abstract: Hydroxyurea is approved for treating children and adults with sickle cell anemia (SCA). Despite its proven efficacy, concerns remain about its mutagenic and carcinogenic potential that hamper its widespread use. Cell culture‐ and animal‐based investigations… read more here.
Keywords: cell; sca patients; mutagenesis; mut ret ... See more keywords
Event related desynchronization and synchronization reveals different dysfunction in SCA with respect to EPM1 patients
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Neurophysiology"
DOI: 10.1016/j.clinph.2018.09.095
Abstract: We evaluated patients with spinocerebellar ataxia (SCA) and Unverricht-Lundborg disease (EPM1) to compare motor related EEG modulation associated with selective cerebellar dysfunction or action myoclonus. We analyzed high-resolution EEG desynchronization/synchronization (ERD/ERS) in alpha and beta… read more here.
Keywords: desynchronization synchronization; epm1 patients; dysfunction; sca ... See more keywords
Induction of macrophages matriptase and activation of macrophage stimulating protein 1 in sickle cell anemia - related chronic kidney disease
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5734971
Abstract: BACKGROUND: More than 50% of sickle cell anemia (SCA) patients develop chronic kidney disease (CKD). The mechanism of CKD is multifactorial and is not yet fully understood. SCA is a vasculopathy associated with multiple mechanisms… read more here.
Keywords: disease; physiology; sca patients; msp1 ... See more keywords
Pulmonary Function Abnormalities in Adults with Sickle Cell Anemia
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DOI: 10.1182/blood-2018-99-114820
Abstract: Sickle cell anemia (SCA) is an inherited red blood cell disorder that leads to hemoglobin polymerization when it deoxygenates. Lung function abnormalities are observed in up to 90% of adults with SCA (PMID: 16556694) and… read more here.
Keywords: function; sca patients; pulmonary function; lung disease ... See more keywords
Manifestations of Reduced Kidney Function Occur at a Higher Estimated Glomerular Filtration Rate in Sickle Cell Anemia
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-124737
Abstract: Kidney disease is a common complication in sickle cell anemia (SCA), which leads to increased morbidity and early mortality. The National Kidney Foundation guidelines use an estimated glomerular filtration rate (eGFR) cutoff of 60 mL/min/1.73m2… read more here.
Keywords: sca patients; min 73m2; research funding; kidney ... See more keywords