Inhibition of colony-stimulating factor 1 receptor early in disease ameliorates motor deficits in SCA1 mice
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DOI: 10.1186/s12974-017-0880-z
Abstract: BackgroundPolyglutamine (polyQ) expansion in the protein Ataxin-1 (ATXN1) causes spinocerebellar ataxia type 1 (SCA1), a fatal dominantly inherited neurodegenerative disease characterized by motor deficits, cerebellar neurodegeneration, and gliosis. Currently, there are no treatments available to… read more here.
Keywords: disease; motor; sca1 mice; factor ... See more keywords