Impaired interactions of ataxin-3 with protein complexes reveals their specific structure and functions in SCA3 Ki150 model
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DOI: 10.3389/fnmol.2023.1122308
Abstract: Spinocerebellar ataxia type 3 (SCA3/MJD) is a neurodegenerative disease caused by CAG expansion in mutant ATXN3 gene. The resulting PolyQ tract in mutant ataxin-3 protein is toxic to neurons and currently no effective treatment exists.… read more here.
Keywords: protein complexes; ki150 model; ataxin protein; model ... See more keywords