Suppression of the yeast elongation factor Spt4 ortholog reduces expanded SCA36 GGCCUG repeat aggregation and cytotoxicity
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research"
DOI: 10.1016/j.brainres.2018.12.045
Abstract: A hexanucleotide GGCCTG repeat expansion in intron 1 of the nucleolar protein 56 gene causes spinocerebellar ataxia type 36 (SCA36), which is a relatively pure cerebellar ataxia with progressive motor neuron involvement. In this study… read more here.
Keywords: repeat; ggccug; elongation factor; sca36 ... See more keywords
The roles of NOP56 in cancer and SCA36
Sign Up to like & getrecommendations! Published in 2023 at "Pathology and Oncology Research"
DOI: 10.3389/pore.2023.1610884
Abstract: NOP56 is a highly conserved nucleolar protein. Amplification of the intron GGCCTG hexanucleotide repeat sequence of the NOP56 gene results in spinal cerebellar ataxia type 36 (SCA36). NOP56 contains an N-terminal domain, a coiled-coil domain,… read more here.
Keywords: cancer sca36; roles nop56; nop56 cancer; domain ... See more keywords