The importance of indole and azaindole scaffold in the development of antitumor agents.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112506
Abstract: With some indoles and azaindoles being successfully developed as anticancer drugs, the design and synthesis of indole and azaindole derivatives with remarkable antitumor activity has received increasing attention and significant progress has been made. This… read more here.
Keywords: scaffold development; azaindole; azaindole scaffold; importance indole ... See more keywords
Acridine: A Scaffold for the development of drugs for Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2023 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026623666230203141543
Abstract: Alzheimer's disease (AD) is drawing scientists' consideration, being one of the gravest diseases mankind will have to battle against in the near future. The number of people with AD is expected to triple in the… read more here.
Keywords: disease; alzheimer disease; scaffold development; acridine scaffold ... See more keywords
The Triprenylated Anthranoid Ferruginin A, a Promising Scaffold for the Development of Novel Antibiotics against Gram-Positive Bacteria
Sign Up to like & getrecommendations! Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11010084
Abstract: In today’s post-antibiotic era, the search for new antimicrobial compounds is of major importance and nature represents one of the primary sources of bioactive molecules. In this work, through a cheminformatics approach, we clustered an… read more here.
Keywords: anthranoid ferruginin; scaffold development; ferruginin; positive bacteria ... See more keywords