Exploring the cycloheptathiophene-3-carboxamide scaffold to disrupt the interactions of the influenza polymerase subunits and obtain potent anti-influenza activity.
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DOI: 10.1016/j.ejmech.2017.06.015
Abstract: With the aim to identify small molecules able to disrupt PA-PB1 subunits interaction of influenza virus (flu) RNA-dependent RNA polymerase, and based on previous structural and computational information, in this paper we have designed and… read more here.
Keywords: carboxamide scaffold; potent anti; exploring cycloheptathiophene; scaffold disrupt ... See more keywords