Discovery of novel piperidine-substituted indolylarylsulfones as potent HIV NNRTIs via structure-guided scaffold morphing and fragment rearrangement.
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DOI: 10.1016/j.ejmech.2016.10.009
Abstract: To further explore the chemical space around the entrance channel of HIV-1 reverse transcriptase (RT), a series of novel indolylarylsulfones (IASs) bearing N-substituted piperidine at indole-2-carboxamide were identified as potent HIV NNRTIs by structure-guided scaffold… read more here.
Keywords: scaffold morphing; structure guided; guided scaffold; hiv nnrtis ... See more keywords