Variations on a scaffold - Novel GABAA receptor modulators.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.07.008
Abstract: Allosteric ligands of GABAA receptors exist in many different chemotypes owing to their great usefulness as therapeutics, with benzodiazepines being among the best known examples. Many allosteric binding sites have been described, among them a… read more here.
Keywords: gabaa receptor; variations scaffold; novel gabaa; gabaa receptors ... See more keywords
3(2H)-pyridazinone derivatives: a new scaffold for novel plant activators
Sign Up to like & getrecommendations! Published in 2019 at "RSC Advances"
DOI: 10.1039/c9ra06892a
Abstract: Due to the emergence of drug resistance, pesticide residue and environmental contamination, it is important to develop novel eco-friendly strategies to protect plants. read more here.
Keywords: pyridazinone derivatives; novel plant; plant activators; new scaffold ... See more keywords
1,4-Dihydropyridine as a Promising Scaffold for Novel Antimicrobials Against Helicobacter pylori
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.874709
Abstract: The increasing occurrence of multidrug-resistant strains of the gastric carcinogenic bacterium Helicobacter pylori threatens the efficacy of current eradication therapies. In a previous work, we found that several 1,4-dihydropyridine (DHP)-based antihypertensive drugs exhibited strong bactericidal… read more here.
Keywords: antimicrobials helicobacter; scaffold novel; promising scaffold; dihydropyridine promising ... See more keywords