Biophysical characterization of Atg11, a scaffold protein essential for selective autophagy in yeast
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12355
Abstract: Autophagy is an intracellular degradation system in which the formation of an autophagosome is a key event. In budding yeast, autophagosomes are generated from the preautophagosomal structure (PAS), in which Atg11 and Atg17 function as… read more here.
Keywords: atg11 scaffold; biophysical characterization; scaffold protein; essential selective ... See more keywords
Afadin (AF6) in cancer progression: A multidomain scaffold protein with complex and contradictory roles
Sign Up to like & getrecommendations! Published in 2020 at "BioEssays"
DOI: 10.1002/bies.202000221
Abstract: Adherens (AJ) and tight junctions (TJ) maintain cell‐cell adhesions and cellular polarity in normal tissues. Afadin, a multi‐domain scaffold protein, is commonly found in both adherens and tight junctions, where it plays both structural and… read more here.
Keywords: cancer; scaffold protein; cancer progression; roles afadin ... See more keywords
Golgi scaffold protein PAQR3 as a candidate suppressor of gastric cardia adenocarcinoma via regulating TGF‐β/Smad pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24617
Abstract: To investigate the function of PAQR3 in gastric cardia adenocarcinoma (GCA) and understand the possible mechanism of PAQR3 in regulating epithelial–mesenchymal transition (EMT). read more here.
Keywords: gastric cardia; golgi scaffold; cardia adenocarcinoma; scaffold protein ... See more keywords
Facile production of tagless membrane scaffold protein for nanodiscs.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2021.114497
Abstract: The initial step in the preparation of nanodiscs is to express and purify the membrane scaffold protein (MSP) to homogeneity. Current methods used for the isolation and purification of MSP utilize nickel affinity chromatography. However,… read more here.
Keywords: tagless; msp; facile production; scaffold protein ... See more keywords
The scaffold protein RACK1 is a target of endocrine disrupting chemicals (EDCs) with important implication in immunity
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2017.04.011
Abstract: ABSTRACT We recently demonstrated the existence of a complex hormonal balance between steroid hormones in the control of RACK1 (Receptor for Activated C Kinase 1) expression and immune activation, suggesting that this scaffold protein may… read more here.
Keywords: endocrine disrupting; rack1; target; scaffold protein ... See more keywords
Glycosylated Peptoid Nanosheets as a Multivalent Scaffold for Protein Recognition.
Sign Up to like & getrecommendations! Published in 2018 at "ACS nano"
DOI: 10.1021/acsnano.7b08018
Abstract: Glycoproteins adhered on the cellular membrane play a pivotal role in a wide range of cellular functions. Their importance is particularly relevant in the recognition process between infectious pathogens (such as viruses, bacteria, toxins) and… read more here.
Keywords: peptoid nanosheets; glycosylated peptoid; recognition; scaffold protein ... See more keywords
Nasal vaccination of triple-RBD scaffold protein with flagellin elicits long-term protection against SARS-CoV-2 variants including JN.1
Sign Up to like & getrecommendations! Published in 2024 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-024-01822-3
Abstract: Developing a mucosal vaccine against SARS-CoV-2 is critical for combatting the epidemic. Here, we investigated long-term immune responses and protection against SARS-CoV-2 for the intranasal vaccination of a triple receptor-binding domain (RBD) scaffold protein (3R-NC)… read more here.
Keywords: sars cov; rbd scaffold; rbd; triple rbd ... See more keywords
A protein-proximity screen reveals Ebola virus co-opts the mRNA decapping complex through the scaffold protein EDC4
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-63392-4
Abstract: The interaction of host and Ebola virus (EBOV) proteins is required for establishing infection. In this study, we use proximity-dependent biotinylation to identify cellular proteins that bind to EBOV proteins encoded by six of the… read more here.
Keywords: decapping complex; scaffold protein; protein; mrna decapping ... See more keywords
Significance of the Tks4 scaffold protein in bone tissue homeostasis
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-42250-6
Abstract: The main driver of osteoporosis is an imbalance between bone resorption and formation. The pathogenesis of osteoporosis has also been connected to genetic alterations in key osteogenic factors and dysfunction of bone marrow mesenchymal stem/stromal… read more here.
Keywords: homeostasis; bone tissue; tks4; tks4 scaffold ... See more keywords
Modular interior loading and exterior decoration of a virus-like particle.
Sign Up to like & getrecommendations! Published in 2017 at "Nanoscale"
DOI: 10.1039/c7nr03018e
Abstract: Virus-like particles (VLPs) derived from the bacteriophage P22 offer an interesting and malleable platform for encapsulation and multivalent presentation of cargo molecules. The packaging of cargo in P22 VLP is typically achieved through genetically enabled… read more here.
Keywords: protein; virus like; p22; scaffold protein ... See more keywords
TRIM22 functions as a scaffold protein for autophagy initiation
Sign Up to like & getrecommendations! Published in 2025 at "Animal Cells and Systems"
DOI: 10.1080/19768354.2025.2498926
Abstract: ABSTRACT Tripartite motif (TRIM) family proteins are increasingly recognized as important regulators of autophagy under various physiological and pathological conditions. TRIM22 has been previously shown to mediate autophagosome-lysosome fusion, but its potential role in earlier… read more here.
Keywords: stages autophagy; scaffold protein; trim22; class iii ... See more keywords