Biophysical characterization of Atg11, a scaffold protein essential for selective autophagy in yeast
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12355
Abstract: Autophagy is an intracellular degradation system in which the formation of an autophagosome is a key event. In budding yeast, autophagosomes are generated from the preautophagosomal structure (PAS), in which Atg11 and Atg17 function as… read more here.
Keywords: atg11 scaffold; biophysical characterization; scaffold protein; essential selective ... See more keywords
Afadin (AF6) in cancer progression: A multidomain scaffold protein with complex and contradictory roles
Sign Up to like & getrecommendations! Published in 2020 at "BioEssays"
DOI: 10.1002/bies.202000221
Abstract: Adherens (AJ) and tight junctions (TJ) maintain cell‐cell adhesions and cellular polarity in normal tissues. Afadin, a multi‐domain scaffold protein, is commonly found in both adherens and tight junctions, where it plays both structural and… read more here.
Keywords: cancer; scaffold protein; cancer progression; roles afadin ... See more keywords
Golgi scaffold protein PAQR3 as a candidate suppressor of gastric cardia adenocarcinoma via regulating TGF‐β/Smad pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24617
Abstract: To investigate the function of PAQR3 in gastric cardia adenocarcinoma (GCA) and understand the possible mechanism of PAQR3 in regulating epithelial–mesenchymal transition (EMT). read more here.
Keywords: gastric cardia; golgi scaffold; cardia adenocarcinoma; scaffold protein ... See more keywords
Facile production of tagless membrane scaffold protein for nanodiscs.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2021.114497
Abstract: The initial step in the preparation of nanodiscs is to express and purify the membrane scaffold protein (MSP) to homogeneity. Current methods used for the isolation and purification of MSP utilize nickel affinity chromatography. However,… read more here.
Keywords: tagless; msp; facile production; scaffold protein ... See more keywords
The scaffold protein RACK1 is a target of endocrine disrupting chemicals (EDCs) with important implication in immunity
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2017.04.011
Abstract: ABSTRACT We recently demonstrated the existence of a complex hormonal balance between steroid hormones in the control of RACK1 (Receptor for Activated C Kinase 1) expression and immune activation, suggesting that this scaffold protein may… read more here.
Keywords: endocrine disrupting; rack1; target; scaffold protein ... See more keywords
Glycosylated Peptoid Nanosheets as a Multivalent Scaffold for Protein Recognition.
Sign Up to like & getrecommendations! Published in 2018 at "ACS nano"
DOI: 10.1021/acsnano.7b08018
Abstract: Glycoproteins adhered on the cellular membrane play a pivotal role in a wide range of cellular functions. Their importance is particularly relevant in the recognition process between infectious pathogens (such as viruses, bacteria, toxins) and… read more here.
Keywords: peptoid nanosheets; glycosylated peptoid; recognition; scaffold protein ... See more keywords
Significance of the Tks4 scaffold protein in bone tissue homeostasis
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-42250-6
Abstract: The main driver of osteoporosis is an imbalance between bone resorption and formation. The pathogenesis of osteoporosis has also been connected to genetic alterations in key osteogenic factors and dysfunction of bone marrow mesenchymal stem/stromal… read more here.
Keywords: homeostasis; bone tissue; tks4; tks4 scaffold ... See more keywords
Modular interior loading and exterior decoration of a virus-like particle.
Sign Up to like & getrecommendations! Published in 2017 at "Nanoscale"
DOI: 10.1039/c7nr03018e
Abstract: Virus-like particles (VLPs) derived from the bacteriophage P22 offer an interesting and malleable platform for encapsulation and multivalent presentation of cargo molecules. The packaging of cargo in P22 VLP is typically achieved through genetically enabled… read more here.
Keywords: protein; virus like; p22; scaffold protein ... See more keywords
The focal adhesion scaffold protein Hic-5 regulates vimentin organization in fibroblasts
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e19-08-0442
Abstract: Focal adhesion (FA)-stimulated reorganization of the F-actin cytoskeleton regulates cellular size, shape, and mechanical properties. However, FA cross-talk with the intermediate filament cytoskeleton is poorly understood. Genetic ablation of the FA-associated scaffold protein Hic-5 in… read more here.
Keywords: vimentin; focal adhesion; protein hic; scaffold protein ... See more keywords
Scaffold coupling: ERK activation by trans-phosphorylation across different scaffold protein species
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.add7969
Abstract: RAS-ERK (extracellular signal–regulated kinase) pathway signals are modulated by scaffold proteins that assemble the components of different kinase tiers into a sequential phosphorylation cascade. In the prevailing model scaffold proteins function as isolated entities, where… read more here.
Keywords: trans phosphorylation; scaffold protein; scaffold proteins; kinase ... See more keywords
Characterization of the Golgi scaffold protein PAQR3, and its role in tumor suppression and metabolic pathway compartmentalization
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Management and Research"
DOI: 10.2147/cmar.s210919
Abstract: Abstract The Golgi apparatus is critical in the compartmentalization of signaling cascades originating from the cytoplasmic membrane and various organelles. Scaffold proteins, such as progestin and adipoQ receptor (PAQR)3, specifically regulate this process, and have… read more here.
Keywords: characterization golgi; golgi; compartmentalization; scaffold protein ... See more keywords