A SCAFFOLD SIMPLIFICATION STRATEGY LEADS TO A NOVEL GENERATION OF DUAL HUMAN IMMUNODEFICIENCY VIRUS AND ENTEROVIRUS-A71 ENTRY INHIBITORS.
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DOI: 10.1021/acs.jmedchem.9b01737
Abstract: Currently there are only three FDA-approved drugs that inhibit HIV entry-fusion into host cells. The situation is even worse for enterovirus EV71 infection for which no antiviral therapies are available. We describe here the discovery… read more here.
Keywords: enterovirus; chemistry; simplification strategy; scaffold simplification ... See more keywords