The phospho–caveolin-1 scaffolding domain dampens force fluctuations in focal adhesions and promotes cancer cell migration
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e17-05-0278
Abstract: The caveolin scaffolding domain mediates the promigratory activity of Src-phosphorylated (on Y14) caveolin-1 and, specifically, regulation of vinculin tension in focal adhesions. This suggests that pY14Cav1 enhances cancer cell migration by promoting engagement of focal… read more here.
Keywords: caveolin scaffolding; scaffolding domain; caveolin; focal adhesions ... See more keywords
Multiple subregions within the caveolin-1 scaffolding domain inhibit fibrosis, microvascular leakage, and monocyte migration
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0264413
Abstract: The caveolin-1 scaffolding domain (CSD, amino acids 82–101 of caveolin-1) has been shown to suppress bleomycin-induced lung and skin fibrosis and angiotensin II (AngII)-induced myocardial fibrosis. To identify active subregions within CSD, we split its… read more here.
Keywords: caveolin scaffolding; microvascular leakage; subregions within; migration ... See more keywords