Vav2 lacks Ca2+ entry-promoting scaffolding functions unique to Vav1 and inhibits T cell activation via Cdc42
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DOI: 10.1242/jcs.238337
Abstract: ABSTRACT Vav family guanine nucleotide exchange factors (GEFs) are essential regulators of immune function. Despite their structural similarity, Vav1 promotes and Vav2 opposes T cell receptor (TCR)-induced Ca2+ entry. By using a Vav1-deficient Jurkat T… read more here.
Keywords: vav2; scaffolding functions; cell activation; vav1 ... See more keywords